Adult Dosing

Severe fungal infections

• 50-150 mg/kg/day PO in divided doses q6 hrs
• Note: To minimize GI upset, give a few capsules at a time over 15 minutes

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• In combination with amphotericin B; treatment of serious infections caused by susceptible strains of Candida and/or Cryptococcus
• Candida infections in septicemia, endocarditis, UTIs and pulmonary infections
• Cryptococcus infections in meningitis, pulmonary, septicemia, and UTIs

• Hypersensitivity to any of the ingredients of the product

• Use with extreme caution in renal impairment; closely monitor hematologic, renal, and hepatic status of all patients
• Review instructions thoroughly before administration

Renal Dose Adjustment

• Renal impairment: Give initial dose at lower range

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Risk of accumulation in renal impairment; monitor hematologic, renal, and hepatic status of all patients before initiating therapy with flucytosine [US Black Box Warning]
• Increases risk of bone marrow suppression when used in the patients with haematologic disease, undergoing treatment with radiation/drugs or history of treatment with radiation/drugs that suppress bone marrow
• Monitor hepatic function and haematological parameters during treatment

Cautions: Use cautiously in

• Renal impairment
• Hepatic impairment
• Bone marrow depression

Supplemental Patient Information

• Instruct patient to report unusual bleeding or bruising

Pregnancy Category:C

Breastfeeding: No reports describing the use of flucytosine during lactation or measuring the amount, if any, excreted in human milk have been located. Manufacturer advices, use taking into account the importance of the drug to the mother, weighing potential benefits as compared to risks.

• CV: Cardiac arrest, myocardial toxicity, ventricular dysfunction
• RESP: Respiratory arrest, chest pain, dyspnea
• DERM: Rash, pruritus, urticaria, photosensitivity
• GI: Nausea, emesis, abdominal pain, diarrhea, anorexia, dry mouth, duodenal ulcer, gastrointestinal hemorrhage, ulcerative colitis, bilirubin elevation, hepatic dysfunction, jaundice, increased hepatic enzymes
• GU: Azotemia, creatinine and BUN elevation, crystalluria, renal failure
• HEMA: Anemia, agranulocytosis, aplastic anemia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia
• CNS: Ataxia, hearing loss, headache, paresthesia, parkinsonism, peripheral neuropathy, vertigo, sedation, convulsions, fatigue
• METABOLIC: Hypoglycemia, hypokalemia
• PSYCHIATRIC: Confusion, hallucinations, psychosis
• MISC: Pyrexia, weakness, allergic reactions, lyell’s syndrome, azotemia

• Antifungal; exact mechanism of action unknown; thought to interfere with protein synthesis in cells of susceptible fungi after conversion to fluorouracil
• Flucytosine is deaminated (probably by gut bacteria) to 5-fluorouracil; CYP450: Unknown
• Excreted in urine 90% (unchanged
• Half life: 2.4-4.8 hrs

US Trade Name(s)

• Ancobon

US Availability

Ancobon

• CAPS: 250, 500 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Antimicrobials

Antifungal

Pricing data from www.DrugStore.com in U.S.A.

• Ancobon 500 MG CAPS [Bottle] (VALEANT)
  30 mg = $2490.11
  90 mg = $7406.78
• Ancobon 250 MG CAPS [Bottle] (VALEANT)
  100 mg = $3067.44
  300 mg = $9189.12

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Drug Name: Ancobon 250 MG Oral Capsule

Ingredient(s): Flucytosine

Imprint: ANCOBON;250;ICN

Color(s): Gray, Green

Shape: Capsule

Size (mm): 18.00

Score: 1

Inactive Ingredient(s): corn starch / lactose / talc / butylparaben / methylparaben / propylparaben / sodium propionate / black iron oxcide / fd&c blue no. 1 / fd&c yellow no. 6 / fd&c yellow no. 10 / titanium dioxide

Drug Label Author:
Valeant Pharmaceuticals, Inc.

DEA Schedule:
Non-Scheduled

Drug Name: Ancobon 500 MG Oral Capsule

Ingredient(s): Flucytosine

Imprint: ANCOBON;500;ICN

Color(s): Gray, White

Shape: Capsule

Size (mm): 18.00

Score: 1

Inactive Ingredient(s): corn starch / lactose / talc / butylparaben / methylparaben / propylparaben / sodium propionate / black iron oxcide / titanium dioxide

Drug Label Author:
Valeant Pharmaceuticals, Inc.

DEA Schedule:
Non-Scheduled