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Interacting Drugs

OBJECT DRUGS

Ergot Alkaloids:

PRECIPITANT DRUGS

Antimicrobials:


Comment:

Ergotamine (and probably dihydroergotamine and methysergide) undergo first-pass metabolism by CYP3A4, and several reports of ergotism have appeared when CYP3A4 inhibitors were given concurrently. Theoretically non-oral routes of ergot administration would interact much less than the oral route.


Class 2: Use Only if Benefit Felt to Outweigh Risk