Adult Dosing

Corticosteroid-responsive dermatoses

• Apply to affected area(s) as a thin film qd-tid, depending on the severity of condition

Pediatric Dosing

• Safety and effectiveness in pediatric patients has not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Inflammatory and pruritic corticosteroid-responsive dermatoses

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

See Supplemental Patient Information

• Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, hyperglycemia and glucosuria occurs due to systemic absorption of topical corticosteroid, application of the more potent steroids over large surface areas, prolonged use and occlusive dressings increase the systemic absorption. Monitor the patient periodically for HPA axis suppression, discontinue or reduce the frequency of application, or substitute with a less potent steroid if HPA- axis suppression noted
• Pediatric patients are more susceptible to systemic toxicity (HPA axis suppression, Cushing's syndrome and intracranial hypertension) as proportionally larger amounts of topical corticosteroids are absorbed
• If irritation develops, discontinue the drug
• If dermatological infection occurs provide appropriate antifungal or antibacterial therapy, temporarily discontinue topical corticosteroid until the infection has been adequately controlled

Caution: Use cautiously in

• Skin infection

Supplemental Patient Information

• Patients should be advised not to bandaged or otherwise covered the affected area(s) unless directed by their physician

Pregnancy Category:C

Breastfeeding: No studies conducted during breastfeeding; short-term application of topical corticosteroids is not expected to pose a risk to the breastfed infant by passage into breastmilk. Use of the least potent drug on the smallest area of skin of mother is recommended. Ensure that the infant's skin does not come into direct contact with the areas treated with this drug. Use of lower potency corticosteroids, water-miscible cream products on the nipple or areola is recommended. Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is applied to the nipple or areola. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 3 Feb 2011). However as per manufacturer data it is unknown whether topical corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk, as many drugs are excreted in human milk caution should be exercised when prescribing topical corticosteroids to lactating women.

• DERM: Burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae, miliaria
• MISC: Adrenal suppression, cushing syndrome
• METABOLIC: Hyperglycemia
• GU: Glucosuria

• Corticosteroid; exact mechanism of action unknown; induce phospholipase A2 inhibitory proteins (lipocortins). These proteins inhibits the release of their common precursor arachidonic acid thereby controlling the biosynthesis of potent inflammatory mediators such as prostaglandins and leukotrienes
• Metabolized primarily by liver; CYP450: Unknown
• Renally excreted; minimally in bile
• Half-life: Unknown

US Trade Name(s)

• ApexiCon
• ApexiCon E

US Availability

diflorasone (generic)

• CRE: 0.05%
• OINT: 0.05%

ApexiCon

• OINT: 0.05%

ApexiCon E

• CRE: 0.05%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Dermatologic

Dermatologic Topical Agents

Steroids

Pricing data from www.DrugStore.com in U.S.A.

• Diflorasone Diacetate 0.05 % CREA [Tube] (TARO)
  15 % = $49.99
  45 % = $129.97
• Diflorasone Diacetate 0.05 % CREA [Tube] (TARO)
  30 % = $99.99
  90 % = $279.96
• Diflorasone Diacetate 0.05 % CREA [Tube] (TARO)
  60 % = $159.99
  180 % = $457.94
• ApexiCon E 0.05 % CREA [Tube] (PHARMADERM)
  60 % = $286.98
  180 % = $845.93
• Diflorasone Diacetate 0.05 % OINT [Tube] (TARO)
  15 % = $55.99
  45 % = $155.98
• Diflorasone Diacetate 0.05 % OINT [Tube] (TARO)
  30 % = $102.99
  90 % = $299.99

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.