Adult Dosing
Prevention of Chemotherapy-Induced Nausea and Vomiting
- 10 mcg/kg IV infusion over 5 minutes or IV injection, within 30 minutes before initiation of chemotherapy; only on the day(s) chemotherapy is given
Postoperative nausea and vomiting
- 1 mg undiluted IV over 30 seconds, before anesthesia or immediately before reversal (prevention) or following symptoms (treatment)
Pediatric Dosing
- Note: Safety and effectiveness in pediatric patients <2 yrs of age have not been established
Prevention of Chemotherapy-Induced Nausea and Vomiting
- 10 mcg/kg IV infusion over 5 minutes or IV injection, within 30 minutes before initiation of chemotherapy; only on the day(s) chemotherapy is given
- Granisetron hydrochloride does not stimulate gastric or intestinal peristalsis; may mask progressive ileus and/or gastric distension
- Patients with cardiac disease, concomitant cardio-toxic chemotherapy or electrolyte abnormalities are at increased risk of QT prolongation
Cautions: Use cautiously in
- Underlying gastrointestinal pathology (may mask progressive ileus/gastric distention)
- Pre-existing arrhythmias or cardiac conduction disorders
- Electrolyte abnormalities
- Recent abdominal surgery
- Cardiac disease
- Concurrent QT prolonging agents
- Concurrent cardiotoxic agents
Pregnancy Category:B
Breastfeeding: Safety not established. Use with caution.
