Adult Dosing

Corticosteroid-responsive dermatoses

• Apply bid

Pediatric Dosing

Corticosteroid-responsive dermatoses

• 1 yrs: Apply cream bid
• >10 yrs: Apply ointment bid

• Safety and efficacy of cream 0.1% in pediatric patients for >3 wks of use have not been established
• Avoid occlusive dressings
• Avoid using in diaper area of small children

[Outline]

• Adult Dosing
• Pediatric Dosing

• For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria have occurred in some patients following systemic; avoid application of more potent steroids over large surface areas during prolonged use and addition of occlusive dressings, as these may augment systemic absorption. Periodically evaluate patients for evidence of HPA axis suppression by performing the urinary free cortisol and ACTH stimulation tests. Also, assess for impairment of internal homeostasis
• On occurrence of HPA axis suppression or elevation of the body temperature, make attempt to withdraw the drug, to reduce the frequency of application, or substitute with a less potent steroid or use a sequential approach while utilizing the occlusive technique
• Contact between drug and latex products (condoms or diaphragm) may reduce latex effectiveness
• Not for vaginal use
• Provide supplemental systemic corticosteroids on occurrence of withdrawal symptoms
• Pediatric patients are more prone to systemic toxicity
• Discontinue therapy on occurrence of irritation or hypersensitivity and provide appropriate therapy
• Institute appropriate antifungal or antibacterial agent for the treatment of dermatological infections. Discontinue use of corticosteroid if a favorable response does not occur promptly until attaining control over the infection

Cautions: Use cautiously in

• Skin infections
• Pediatric patients

Pregnancy Category:C

Breastfeeding: Safety unknown; manufacturer advises caution when topical corticosteroids are administered to a nursing woman.

• DERM: Acneiform eruptions, burning, miliaria. itching, irritation, dryness, folliculitis, hypertrichosis, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration, secondary infection, skin atrophy, striae, pruritus, prednicarbate
• ENDO: HPA axis suppression, Cushing syndrome, hyperglycemia
• CNS: Intracranial hypertension

• Corticosteroid; precise mechanism of action for dermatologic actions unknown; exerts anti-inflammatory, antipruritic and vasoconstrictive actions
• Absorbed from intact skin
• Primarily metabolized by liver; CYP450: Unknown
• Excreted in urine
• Half life: Unknown

US Trade Name(s)

• Dermatop
• Dermatop E Emollient

US Availability

prednicarbate (generic)

• OINT: 0.1 %
• CRE: 0.1 %

Dermatop

• OINT: 0.1 %

Dermatop E Emollient

• CRE: 0.1 %

Canadian Trade Name(s)

• Dermatop
• Dermatop Emollient

Canadian Availability

Dermatop

• OINT: 0.1 %

Dermatop Emollient

• CRE: 0.1 %

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Dermatologic

Dermatologic Topical Agents

Steroids

Pricing data from www.DrugStore.com in U.S.A.

• Prednicarbate 0.1 % CREA [Tube] (PRASCO LABORATORIES)
  15 % = $26.99
  45 % = $65.97
• Dermatop 0.1 % CREA [Tube] (DERMIK)
  60 % = $75.21
  180 % = $201.64
• Prednicarbate 0.1 % CREA [Tube] (PRASCO LABORATORIES)
  60 % = $55.99
  180 % = $149.97
• Prednicarbate 0.1 % OINT [Tube] (FOUGERA)
  15 % = $36.99
  45 % = $93.97
• Prednicarbate 0.1 % OINT [Tube] (FOUGERA)
  60 % = $72.99
  180 % = $200.96
• Dermatop 0.1 % OINT [Tube] (DERMIK)
  60 % = $65.99
  180 % = $179.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.