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Interacting Drugs

OBJECT DRUGS

NSAIDs:

PRECIPITANT DRUGS

Aldosterone Antagonists:


Comment:

The concurrent use of NSAIDs with aldosterone antagonists appears to increase the risk of gastrointestinal (GI) bleeding compared to either drug used alone. Although the vast majority of patients on concurrent therapy with an NSAID and an aldosterone antagonist will not develop GI bleeding, the potential severity of the outcome (including death) suggests that the risk should be avoided if possible.


Class 3: Assess Risk & Take Action if Necessary