Adult Dosing

Postmenopausal osteoporosis

• 200 units (1 SPRAY) daily alternating nostrils every day

Pediatric Dosing

• Safety and effectiveness in pediatric patients has not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• For the treatment of post-menopausal osteoporosis

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Perform periodic nasal exams; discontinue if severe ulceration occurs
• Supplement diet with calcium (at least 1 g/day) and Vit.D (400 units/day); reevaluate periodically
• Skin testing should be considered prior to treatment for patients with suspected sensitivity to calcitonin
• Perform period examinations of urine sediment
• Due to the possible association between malignancy and calcitonin-salmon use, the need for continued therapy should be re-evaluated on a periodic basis

Cautions: Use with caution in

• Prior bisphosphonate use
• Elderly patients

Supplemental Patient Information

• Instruct patient to notify their physician if they develop significant nasal irritation
• After 30 doses, each spray may not deliver the correct amount of medication, even if the bottle is not completely empty. Hence, instruct patients to keep track of the number of doses used from the bottle

Pregnancy Category:C

Breastfeeding: Safety undetermined, use not recommended.

• EENT: Rhinitis, symptom of Nose, epistaxis, sinusitis
• MUSC: Back Pain, arthralgia
• CNS: Headache
• RESP: Bronchospasm
• MISC: Hypersensitivity reaction, anaphylaxis

• Hormone; directly affects bone, kidney, and GI tract. Decreases osteoclastic osteolysis in bone; also reduces mineral release and collagen breakdown in bone and promotes renal excretion of calcium
• Bioavailability relative to IM administration is between 3 and 5%
• Primarily and almost exclusively degraded in the kidneys
• Excreated in urine (0.1% unchanged)
• Half-life: 43 minutes

US Trade Name(s)

• Miacalcin

US Availability

calcitonin-salmon (generic)

• Metered nasal SPRAY: 200 Units/Spray

Miacalcin

• Metered nasal SPRAY: 200 Units/Spray

Canadian Trade Name(s)

• Miacalcin

Canadian Availability

calcitonin-salmon (generic)

• Metered nasal SPRAY: 200 Units/Spray

Miacalcin

• Metered nasal SPRAY: 200 IU/actuation

UK Trade Name(s)

• Miacalcin

UK Availability

Miacalcin

• Metered nasal SPRAY: 200 Units/Spray

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Endocrine/Metabolic

Hypocalcemics

Hormones

Pricing data from www.DrugStore.com in U.S.A.

• Miacalcin 200 UNIT/ACT SOLN [Bottle] (NOVARTIS)
  3.7 act = $145.99
  7.4 act = $279.96

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.