Adult Dosing
Hypoglycemia due to hyperinsulinism
- 3-8 mg/kg/day PO divided q8-12 hrs. Start: 3 mg/kg/day PO divided q8 hrs
- Max: 8 mg/kg/day PO divided q8-12 hrs
Pediatric Dosing
Hypoglycemia due to hyperinsulinism
- 0-23 months: 8-15 mg/kg/day divided q8-12 hours. Start: 10 mg/kg/day PO divided q8 hrs
- >2 years: 3-8 mg/kg/day divided q8-12 hours. Start: 3 mg/kg/day PO divided q8 hrs
[Outline]
See Supplemental Patient Information
- Fluid retention and precipitation of congestive heart failure may occur due to antidiuretic property of diazoxide in patients with compromised cardiac reserve
- Therapy may cause ketoacidosis and nonketotic hyperosmolar coma usually during concomitant illness. Administer appropriate therapy and prolonged monitoring should be done following the acute episode
- Events of transient cataracts occurred in association with hyperosmolar coma in an infant have been reported with the therapy
- Chronic use (> 4 years) may cause abnormal facial features in children
- Initiate therapy under close clinical supervision with careful monitoring of blood glucose and clinical response until the patient's condition has stabilized
- Monitor hematopoietic system and the level of serum uric acid in patients with hyperuricemia or a history of gout
- Appropriate dosage adjustments should be made as necessary in individual patients if changed from one formulation to the other
- Therapy may enhance antihypertensive effect of other drugs. Administer cautiously when administering in combination with antihypertensive agents
- Caution advised when treating newborns with increased bilirubinemia as therapy may possibly displace bilirubin from albumin
Cautions: Use cautiously in
- Renal impairment
- Hyperuricemia
- Hx of gout
- Hyperbilirubinemia
- Diabetes mellitus
- Impaired cardiac function
- Concurrent antihypertensives
- 3rd trimester
- Labor and delivery
- CHF
Supplemental Patient Information
- Carefully monitor blood glucose, urine and ketones
- Promptly report abnormal findings and unusual symptoms to the physician
Pregnancy Category:C
Breastfeeding: Safety unknown; decision should be made whether to discontinue nursing or discontinue drug after assessing risk/benefit and importance of the drug to the mother.
Pricing data from www.DrugStore.com in U.S.A.
- Proglycem 50 MG/ML SUSP [Bottle] (GATE)
30 ml = $199.99
90 ml = $579.96
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
