Adult Dosing
Assisted Reproductive Technology
- Progesterone supplementation: 90 mg qd vaginally x 10-12 wk
- Partial or complete ovarian failure: 90 mg bid vaginally x 10-12 wk
Secondary Amenorrhea
- 45 mg qod x 6 doses
- Max: 90 mg x 6 doses
Note:
- If pregnancy occurs treatment should be continue till the placental autonomy is achieved or for 10-12 wks
- Increase in dose i.e. 4% to 8%, does not increase the absorption of drug
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
[Outline]
See Supplemental Patient Information
- Maintain alertness to the earliest manifestations of thrombotic disorders; on suspicion or occurrence of these events immediately discontinue therapy
- Efficacy has not been established to prevent miscarriage in women with a history of recurrent spontaneous pregnancy losses
- Examine breast, pelvic organs as well as Papanicolaou smear before undergoing therapy
- Consider nonfunctional causes in all cases of irregular vaginal bleeding. Undertake adequate diagnostic measures in cases of undiagnosed vaginal bleeding
- Some degree of fluid retention influencing epilepsy, migraine, asthma, cardiac or renal dysfunction have occurred; careful monitoring is essential
- Inform pathologist of progesterone therapy when relevant specimens are submitted
- Carefully observe patients having a history of psychic depression and discontinue therapy if the depression recurs to a serious degree
- Carefully monitor diabetic patients while receiving progestin therapy as decrease in glucose tolerance is observed
Cautions: Use cautiously in
- Renal impairment
- Cardiac disease
- Diabetes mellitus
- History of psychic disorder
- Epilepsy
- Depression
- Undiagnosed vaginal bleeding
- Asthma
- Migraine
Supplemental Patient Information
- Instruct patients to avoid concomitant use with other local intravaginal therapy; keep at least 6 hr period before or after progesterone administration if other local intravaginal therapy is to be used concurrently
- Inform patients that vaginal discharge in the form of small, white globules may appear possibly due to gel accumulation, even several days after usage
Pregnancy Category:C
Breastfeeding: Probably Safe, very less amount of progesterone is excreted, which would not cause any adverse effects in breastfed infants; no special precautions are needed. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 3 January 2010). According to manufacturer's data, detectable amount of drug have been detected in mother milk. The effect of drug on nursing infant has not been determined.
Pricing data from www.DrugStore.com in U.S.A.
- Prochieve 4 % GEL [Tube] (WATSON LABS)
26.1 % = $159.99
78.3 % = $454.98 - Crinone 8 % GEL [Tube] (WATSON LABS)
1.45 % = $25.99
2.9 % = $39.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
