Adult Dosing
Acne vulgaris (grades I, II, and III)
tretinoin, Atralin, Avita, Retin-A, Retin-A Micro, Tretin-X
- Apply qhs to the affected areas
Fine wrinkles, mottled hyperpigmentation, tactile roughness
Renova, tretinoin 0.05%, Refissa
- 0.02% cream: Apply a thin film qhs; Max: 52 wks
- 0.05% cream: Apply a thin film qhs; Max: 48 wks
Pediatric Dosing
Acne vulgaris (grades I, II, and III)
Atralin
- >10 yrs: Apply qhs to the affected areas
Avita, Retin-A, Retin-A Micro
- >12 yrs: Apply qhs to the affected areas
Note:Safety and effectiveness of Refissa in patients < 18 years of age have not been established Safety and effectiveness of Tretin-X in pediatric patients < 12 years of age have not been established
[Outline]
tretinoin cream 0.05%, Altralin, Avita, Retin-A, Retin-A Micro, Tretin-X
- Treatment of acne vulgaris
Renova, Refissa
- As an adjunct for use in the mitigation (palliation) of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin in patients who are using comprehensive skin care and sunlight avoidance programs
See Supplemental Patient Information
- Safety and effectiveness of 0.05% cream and 0.02% cream daily for >48 wks and >52 wks respectively have not been established. On treatment for >48 wks atypical changes in melanocytes and keratinocytes, and of increased dermal elastosis may occur
- Safety and effectiveness of in individuals with moderately or heavily pigmented skin have not been evaluated
- Avoid administration of this drug to the patients treated with photosensitizers as possibility of augmented phototoxicity exists
- Avoid unprotected exposure to sunlight
- Severe local erythema, pruritus, burning, stinging, and peeling may occur at the site of application
- Severe irritation on eczematous skin may occur; advise patients to exercise caution in such instances
- Marked redness, peeling, or discomfort may occur on exceeding recommended doses
- Use 0.05% cream only as an adjunct to a comprehensive skin care and sunlight avoidance program
- Discontinue use of this drug on development of drug sensitivity, chemical irritation, or a systemic adverse reaction
- Extreme weather such as wind or cold are more irritating to patients using tretinoin containing products
- Exercise caution during use of topical gel inpatients with known sensitivity to fish
Cautions: use cautiously in
- Photosensitivity
- Sunburn
- Eczema
- Concomitant use with skin irritant
- Concomitant use of photosensitizers (thiazides, tetracyclines, fluroquinolones, phenothiazines, sulfonamides)
Supplemental Patient Information
- Instruct patients to avoid or minimize exposure to sunlight (including sunlamps)
- Warn patients to use sunscreens (minimum SPF of 15) and protective clothing during therapy
- Advise patients with sunburn to avoid use of this drug until full recovery
- Advise patients to avoid exposure of this drug to eyes, mouth, angles of the nose, and mucous membranes
- Direct patients to use less amount of medication, reduce the frequency of application, temporarily or permanently discontinue therapy and consider additional appropriate therapy if the degree of local irritation warrants
Pregnancy Category:C
Breastfeeding: Safety unknown; no formal studies for the use of topical tretinoin during breastfeeding have been conducted. Due to minimal systemic absorption following topical administration, it is considered a low risk to the nursing infant. Infant's skin should not come in direct contact with the areas of the skin that have been treated. Apply only water-miscible cream products to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 16 June 2011). For use of tretinoin (Renova) manufacturer advises to postpone therapy in nursing mothers until after completion of the nursing period. For use of tretinoin (Altralin, Avita, Retin-A, Retin-A Micro) in nursing mothers manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Retin-A Micro Pump 0.04 % GEL [Pump Btl] (ORTHO DERM)
50 % = $319.19
150 % = $907.11 - Retin-A 0.1 % CREA [Tube] (VALEANT)
45 % = $270.98
135 % = $780.97 - Refissa 0.05 % CREA [Tube] (VALEANT)
40 % = $145.98
120 % = $409.95 - Retin-A 0.1 % CREA [Tube] (VALEANT)
20 % = $146.6
60 % = $411.99 - Retin-A 0.01 % GEL [Tube] (VALEANT)
45 % = $197.13
135 % = $557.31 - Renova 0.02 % CREA [Tube] (VALEANT)
60 % = $244.98
180 % = $684.99 - Tretinoin 0.05 % CREA [Tube] (PERRIGO PHARMACEUTICALS)
45 % = $76.99
135 % = $215.98 - Tretinoin 0.025 % GEL [Tube] (PERRIGO PHARMACEUTICALS)
15 % = $34.99
45 % = $89.97 - Tretinoin 0.01 % GEL [Tube] (PERRIGO PHARMACEUTICALS)
15 % = $35.99
45 % = $96.97 - Retin-A 0.05 % CREA [Tube] (VALEANT)
20 % = $127.99
60 % = $355.96 - Retin-A Micro 0.1 % GEL [Tube] (VALEANT)
20 % = $152.32
60 % = $425.6 - Retin-A 0.05 % CREA [Tube] (VALEANT)
45 % = $240.1
135 % = $663.47 - Retin-A Micro 0.1 % GEL [Tube] (VALEANT)
45 % = $275.52
135 % = $769.41 - Tretin-X 0.0375 % CREA [Tube] (TRIAX PHARMACEUTICALS)
35 % = $209.53
105 % = $600.01 - Renova 0.02 % CREA [Tube] (VALEANT)
40 % = $195.98
80 % = $364.98 - Retin-A Micro 0.04 % GEL [Tube] (VALEANT)
20 % = $145.99
60 % = $402.95 - Retin-A Micro 0.04 % GEL [Tube] (VALEANT)
45 % = $268.98
135 % = $758.97 - Avita 0.025 % GEL [Tube] (MYLAN)
45 % = $160.58
135 % = $439.94 - Retin-A 0.01 % GEL [Tube] (VALEANT)
15 % = $130.16
45 % = $379.14 - Avita 0.025 % CREA [Tube] (MYLAN)
20 % = $92.38
60 % = $250.77 - Avita 0.025 % CREA [Tube] (MYLAN)
45 % = $189.99
135 % = $525.94 - Renova Pump 0.02 % CREA [Pump Btl] (ORTHO DERM)
44 % = $209.98
132 % = $587.98 - Retin-A 0.025 % CREA [Tube] (VALEANT)
45 % = $197.15
135 % = $556.04 - Retin-A 0.025 % GEL [Tube] (VALEANT)
15 % = $96.05
45 % = $260.33 - Retin-A 0.025 % GEL [Tube] (VALEANT)
45 % = $190.83
135 % = $551.03 - Retin-A 0.025 % CREA [Tube] (VALEANT)
20 % = $113.73
60 % = $315.9 - Retin-A Micro Pump 0.1 % GEL [Pump Btl] (ORTHO DERM)
50 % = $315.98
150 % = $899.99 - Tretinoin 0.025 % GEL [Tube] (PERRIGO PHARMACEUTICALS)
45 % = $79.99
135 % = $227.98
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
