Class 1: Avoid Combination (Risk of combination outweighs benefit)

Class 2: Usually Avoid Combination (Use only under special circumstances)

• Interactions for which there are clearly preferable alternatives for one or both drugs.
• Interactions to avoid by using an alternative drug or other therapy unless the benefit is judged to outweigh the increased risk.

Class 3: Minimize Risk (Assess risk and take one or more of the following actions if needed)

• Consider alternatives: Alternatives may be available that are less likely to interact
• Circumvent: Take action to minimize the interaction (without avoiding combination.)
• Monitor: Early detection can minimize the risk of an adverse outcome.