Adult Dosing
Tuberculosis mainly multi-drug resistant TB (MDR-TB)
- 4 g PO tid
- Administer by sprinkling on apple sauce or yogurt or by swirling with in an acidic drink such as tomato or orange juice
Pediatric Dosing
Tuberculosis mainly multi-drug resistant TB (MDR-TB)
Children >15 yrs
- 4 g PO tid
- Administer by sprinkling on apple sauce or yogurt or by swirling with in an acidic drink such as tomato or orange juice
Children <15 yrs
- 200-300 mg/kg PO divided bid-qid
- Administer by sprinkling on apple sauce or yogurt or by swirling with in an acidic drink such as tomato or orange juice
[Outline]
See Supplemental Patient Information
- Drug-induced hepatitis has been reported in 0.5% of the patients within three months of aminosalicylic acid therapy. Monitor the patient carefully for first 3 months of therapy and discontinued immediately at the first sign of a rash, fever or other premonitory signs of intolerance
- Aminosalicylic acid therapy can cause hypersensitivity reaction, discontinue the drug immediately and can restart it cautiously
- Desensitization can be obtained by starting slowly with 10 mg aminosalicylic acid given as a single dose, then double it every 2 days until reaching a total of 1 gram, then follow the regular schedule of administration. Drop back by one level if mild temperature rise or skin reaction develops
Cautions: Use cautiously in
- Hepatic impairment
- Crystalluria
Supplemental Patient Information
- Advise patients to report the first signs of hypersensitivity including rash, fever immediately to their clinician
- Patients should be warned that poor compliance in taking anti-TB medication often leads to treatment failure and development of resistance of the organisms
Pregnancy Category:C
Breastfeeding: Low levels of aminosalicylic acid are excreted in milk and are not expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. If this drug is used during lactation, monitor exclusively breastfed infants for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 27 June 2011). As per manufacturer data maximum concentration of aminosalicylic acid in the milk, after administration of a different preparation was 1 mg/mL at 3 hrs with a half-life of 2.5 hrs; the maximum maternal plasma concentration was 70 mg/mL at two hrs.
