Adult Dosing
Upper respiratory tract infections
Pharyngitis/Tonsillitis
- 500 mg PO q24 hrs x 10 days
Acute sinusitis
- Mild: 250 mg PO q12 hrs x 10 days
- Mod to Severe: 500 mg PO q12 hrs x 10 days
Lower respiratory tract infections
- 500 mg PO q12 hrs x 10 days
Skin/Skin structure infections, umcomplicted bacterial
- 250-500 mg PO q12 hrs x 10 days
- Alt: 500 mg PO q24 hrs x 10 days
Pediatric Dosing
Otitis media
Child (6 months-12 yrs)
- 30 mg/kg/day PO divided q12 hrs x 10 days
- Max: 1000 mg/day
Acute sinusitis
Child (6 months-12 yrs)
- 15-30 mg/kg/day PO divided q12 hrs x 10 days
- Max: 1000 mg/day
Pharyngitis/tonsillitis
Child (2-12 yrs)
- 15 mg/kg/day PO divided q12 hrs x 10 days
- Max: 1000 mg/day
Skin/Skin structure infections, umcomplicted bacterial
Child (2-12 yrs)
- 20 mg/kg PO q24 hrs x 10 days
- Max: 1000 mg/day
[Outline]
Renal Dose Adjustment (Based on CrCl)
- > 30 mL/min: Give usual dose
- < 30 mL/min: Reduce dose by 50%
- HD: Administer after the hemodialysis session
Hepatic Dose Adjustment
- Hepatic impairment: No dose adjustments
- Before starting therapy with cefproxil, carefully inquire if patients have had previous hypersensitivity to cephalosporins, penicillins or other b-lactams. Extreme caution must be exercised as cross reactivity among beta-lactam antibiotics is clearly documented and may occur in up to 10% of patients
- If an allergic reaction occurs, discontinue use and institute appropriate therapeutic measures
- Cefproxil should be used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. Prescribing in the absence of a proven or strongly suspected bacterial infection increases the risk of the development of drug-resistant bacteria
- Obtain culture and susceptibility tests before starting therapy to determine the susceptibility of the causative organisms
- Clostridium difficile associated diarrhea which may vary in severity from mild to fatal colitis, has been reported with use of cephalosporins
- Prolonged use may result in the overgrowth of nonsusceptible organisms
Cautions: Use cautiously in
- Renal impairment
- Concurrent nephrotoxic agents
- Hypersensitivity to penicillins
- Hx of GI disease
- Seizure disorder
Pregnancy Category:B
Breastfeeding: This drug is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776) and based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 17 May 2010).Manufacturer advises caution as small amounts have been detected in human milk.
Pricing data from www.DrugStore.com in U.S.A.
- Cefprozil 500 MG TABS [Bottle] (LUPIN PHARMACEUTICALS)
50 mg = $350.99
150 mg = $1020 - Cefzil 250 MG/5ML SUSR [Bottle] (B-M SQUIBB U.S. (PRIMARY CARE))
100 5ml = $73.99
300 5ml = $212.97 - Cefzil 250 MG TABS [Bottle] (B-M SQUIBB U.S. (PRIMARY CARE))
20 mg = $109.99
60 mg = $305.96 - Cefzil 250 MG/5ML SUSR [Bottle] (B-M SQUIBB U.S. (PRIMARY CARE))
50 5ml = $45.99
150 5ml = $115.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
