Adult Dosing
Adjunct therapy for weight gain/Corticosteroid induced protein catabolism
- 2.5-20 mg PO bid-qid x 2-4 wks, may repeat intermittently as indicated
- Geriatric: 5 mg PO bid
- Max: 20 mg/day
Bone pain associated with osteoporosis
- 2.5-20 mg PO bid-qid x 2-4 wks, may repeat intermittently as indicated
- Geriatric: 5 mg PO bid
- Max: 20 mg/day
Pediatric Dosing
Adjunct therapy for weight gain/Corticosteroid induced protein catabolism
0.1 mg/kg or less or 0.045 mg/lb or less PO qd x 2-4 wks- May repeat intermittently as indicated
[Outline]
See Supplemental Patient Information
- Cholestatic hepatitis and jaundice have been reported with 17-alpha-alkylated androgens at a relatively low dose. Discontinue the treatment on the occurrence of cholestatic hepatitis with jaundice or abnormal liver function and determine the etiology. Drug induced jaundice is reversible on discontinuation of drug
- Anabolic steroids can cause hypercalcemia in patients with breast cancer, by stimulating osteolysis. Discontinue the drug if hypercalcemia occurs
- Concomitant administration of adrenal cortical steroid or ACTH in patients with pre-existing cardiac, renal, or hepatic disease, increases edema
- Accelerated bone maturation without producing compensatory gain in linear growth, resulting into compromised adult height, has been reported in pediatric patients on androgen therapy. The younger the child, the greater the risk, monitor bone maturation by assessing bone age of the left wrist and hand every 6 months
- Geriatric patients on androgenic anabolic steroids therapy are at higher risk of prostatic hypertrophy and prostatic carcinoma
- Athletic ability is not enhanced by anabolic steroids
- Decrease warfarin dose to maintain desirable INR level and to diminish the risk of potentially serious bleeding when oxandrolone is prescribed concomitantly, as it can result in unexpectedly large increases in the International Normalized Ratio (INR) or prothrombin time (PT)
- Monitor female patients on oxandrolone therapy for signs of virilization (deepening of the voice, hirsutism, acne, clitoromegaly) and discontinue the therapy at evidence of mild virilism, to prevent irreversible virilization
- Menstrual irregularities can occur with androgen therapy
- Suppression of clotting factors II, V, VII, and X, and an increase in prothrombin time have been observed with anabolic steroids
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- CHF
- Cardiac diseases
- Anticoagulant use
- Bleeding disorders
- Hyperlipidemia
- Pediatric patients
- Elderly patients
- Edema
Supplemental Patient Information
- Instruct the patient to inform immediately if any use of warfarin and any bleeding
- Instruct the patient to report their physician if frequent or persistent erections of the penis occur in male patients, and hoarseness, acne, changes in menstrual periods, or more facial hair is observed in female patients and also if nausea, vomiting, changes in skin color, or ankle swelling occurs
Pregnancy Category:X
Breastfeeding: Safety Unknown; because of the potential for possible serious adverse reactions in nursing infants manufacturer recommends discontinuation of breastfeeding, or postponing of treatment (taking into account the importance of the drug to the mother).
Pricing data from www.DrugStore.com in U.S.A.
- Oxandrin 10 MG TABS [Bottle] (SAVIENT PHARMACEUTICALS INC.)
30 mg = $822.73
60 mg = $1621.34 - Oxandrolone 10 MG TABS [Bottle] (WATSON LABS)
30 mg = $545.98
90 mg = $1580.05 - Oxandrin 2.5 MG TABS [Bottle] (SAVIENT PHARMACEUTICALS INC.)
30 mg = $249.24
90 mg = $725.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
