Reduction in risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
- CrCl >50 mL/min: 20 mg PO qday with the evening meal
- CrCl 15 to 50 mL/min: 15 mg PO qday with the evening meal
- 15 mg PO bid x 21 days with food, then 20 mg PO qday for remaining treatment
Reduction in the risk of recurrence of DVT and of PE
- 20 mg PO qday with food
Prophylaxis of DVT, which may lead to PE in patients undergoing knee or hip replacement surgery
- Hip replacement: 10 mg PO qday x 35 days
- Knee replacement: 10 mg PO qday x 12 days
Note:
- Refer to package insert for information when switching from or to warfarin or other anticoagulants
- If missed dosage 15 mg x PO bid , then take two tablets of 15 mg immediately to ensure intake of 30 mg/day, and continue with regular dose. If missed any of the doses i.e 20, 15, or 10 mg once daily , then take the missed dose immediately
Symptomatic Pulmonary Embolism [Non-FDA Approved]
- 15 mg PO bid for 3 weeks, followed by 20 mg qd
- Safety and effectiveness in patients < 18 yrs of age have not been established
