Adult Dosing
Locally Advanced Basal Cell Carcinoma (BCC)
- Recommended dose: 200 mg PO qd
- Dose should be taken on empty stomach, at least 1 hour before or 2 hours after a meal
Note:
- Establish the pregnancy status of females of reproductive potential before initiating sonidegib treatment
- Obtain serum creatine kinase (CK) levels and renal function tests before initiating sonidegib treatment in all patients
- If a dose is missed, resume dosing with the next scheduled dose
- Dose modifications: Refer package insert
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Pregnancy Category: Not rated
- Mechanism of action and data from animal reproduction studies suggest that sonidegib can cause fetal harm when administered to a pregnant woman. However, data on its use in pregnant women are not available
Breastfeeding: Manufacturer advises not to breastfeed during treatment with sonidegib and for 20 months after the last dose
ULN and AST > ULN or Total bilirubin >1-1.5 x ULN: No dose adjustments
