Renal Dose Adjustment (Based on CrCl)
- > 50 mL/min: Decrease dose by 50%
- < 50 mL/min: Avoid use
Hepatic Dose Adjustment
- Hepatic impairment: Use with caution; dose adjustments not defined
- Oral hypoglycemic drugs increase risk of cardiovascular mortality compared to treatment with diet alone or diet plus insulin: results of University Group Diabetes program, a long-term prospective clinical trial which evaluated effectiveness of glucose-lowering drugs in preventing/delaying vascular complications in patients w/ non-insulin dependent diabetes
- Risk of severe hypoglycemia, which may result in coma and require hospitalization
- Use in pts with G6PD deficiency may cause hemolytic anemia, Non-sulfonylurea alternative should be considered
- Administration with alcohol may induce disulfiram-like syndrome with facial flushing and breathlessness
- Infection, stress, or changes in diet may alter requirements for control of blood sugar
- Proper patient selection, dosage, and instructions are important to avoid hypoglycemic episodes
- Monitor blood glucose and Hb1Ac levels at appropriate intervals
Cautions: Use cautiously in
- Hepatic or renal impairment
- Severe cardiovascular disease
- Hypoglycemia
- Malnutrition
- High fever
- Prolonged nausea or vomiting
- Impaired thyroid, pituitary, or adrenal function
- G6PD deficiency
- Geriatric patients
Pregnancy Category:C
Breastfeeding: Possibly unsafe; excreted in breastmilk.
Pricing data from www.DrugStore.com in U.S.A.
- ChlorproPAMIDE 100 MG TABS [Bottle] (MYLAN)
60 mg = $30.99
180 mg = $85.97 - Diabinese 250 MG TABS [Bottle] (PFIZER U.S.)
60 mg = $79.99
180 mg = $219.98 - ChlorproPAMIDE 250 MG TABS [Bottle] (MYLAN)
60 mg = $55.99
180 mg = $145.98
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
