Adult Dosing

Pyridoxine deficiency

• 10-20 mg/day PO for 3 weeks then 2-5 mg/day as a supplement

Drug-Induced Neuropathy

• 25-50 mg/day

Pediatric Dosing

Pyridoxine deficiency

Prophylaxis

• Child >14 yrs: 1.2–1.7 mg/day PO
• Child 9-13 yrs: 1 mg/day PO
• Child 1-8 yrs: 0.5–0.6 mg/day PO
• Infants 6–12 months: 0.3 mg/day PO
• Infants <6 months: 0.1 mg/day PO

Treatment

• 5–25 mg/day PO x3 wks, then 1.5–2.5 mg/day PO

Pyridoxine-Dependent Seizures

• Neonates and Infants: 10–100 mg initially then 50-100 mg/day PO

Drug-Induced Neuropathy

Treatment

• 10-50 mg/day PO

Prophylaxis

• 1-2 mg/day

• Treatment and prevention of pyridoxine deficiency (may be associated with poor nutritional status or chronic debilitating illnesses)
• Treatment of pyridoxine-dependent seizures in infants
• Treatment and prevention of neuropathy, which may develop from isoniazid, penicillamine, or hydralazine therapy

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Patients with Parkinson’s disease on levadopa treatment should not take supplemental pyridoxine more than
• Long term use of large doses may produce pyridoxine-dependency syndrome in newborn

Pregnancy Category:A

Breastfeeding: Probably safe. This drug is compatible and considered safe with breastfeeding based upon data from the AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 last accessed 18 May 2011).

• GI: Nausea, headache
• CNS: Paresthesia, somnolence
• HEPA: Increased serum AST (SGOT), decreased serum folic acid concentrations
• HYPERSENSITIVITY: Allergic reactions

• Water soluble vitamin; acts as a coenzyme in the metabolism of protein, carbohydrate, and fat
• Metabolized by liver
• Renally excreted as metabolites
• Half-life: 15-20 days

US Trade Name(s)

• Only generic available

US Availability

pyridoxine (generic)

• TABS: 20, 25, 50, 100, 200, 250, 500 mg
• ETABS: 100, 200, 500 mg
• ECAPS: 150 mg
• SOLN: 200 mg/5 mL

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Only generic available

Australian Availability

pyridoxine (generic)

• TABS: 100 mg

Nutrition/Electrolytes

Vitamins