Adult Dosing

Pyridoxine deficiency

• 10-20 mg/day IM/IV x 3 wks, then give 2-5 mg PO qd as a daily supplement

Isoniazid overdose

• 1-4 g IV followed by 1 g IM q30 mins until pyridoxine dose equal to isoniazid dose has been given

Pediatric Dosing

Pyridoxine-dependent seizures in neonates and infants

• 10-100 mg/day IM/IV

[Outline]

• Adult Dosing
• Pediatric Dosing

• Pyridoxine deficiency
• Drug-induced pyridoxine deficiency
• Pyridoxine-dependent seizures in neonates and infants
• As an adjunct in the treatment of acute toxicity resulting from isoniazid (INH), cycloserine, or hydrazine overdose
• Prevention or treatment of drug-induced (isoniazid, ethionamide, or capecitabine) neurotoxicity
• As an adjunct in the treatment of mushroom poisoning

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Patients on levadopa treatment should not take supplemental pyridoxine more than 5 mg/day
• Women on oral contraceptive may require increased quantity of the drug
• Withdrawal of pyridoxine after 200mg/day dose may give the symptoms of dependence

Pregnancy Category:A

Breastfeeding: Probably safe. This drug is compatible and considered safe with breastfeeding based upon data from the AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 last accessed 25 November 2010). Manufacturer advises caution.

• CNS: Sensory neuropathy, paresthesia, unstable gait, numbness, pyridoxine-induced neurotoxicity, headache, somnolence, seizures
• GI: Nausea
• LOCAL: Burning or stinging at the site of injection
• HYPERSENSITIVITY: Allergic reactions
• LABTEST:High serum aspartate aminotransferase, low serum folic acid levels

• Vitamin; acts as a coenzyme in the metabolism of protein, carbohydrate, and fat
• Metabolized by liver
• Renally excreted as metabolites
• Half-life: 15-20 days

US Trade Name(s)

• Only generic available

US Availability

pyridoxine (generic)

• INJ: 100 mg/mL

Canadian Trade Name(s)

• Only generic available

Canadian Availability

pyridoxine (generic)

• INJ: 100 mg/mL

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Nutrition/Electrolytes

Vitamins

Water-soluble B Complex Vitamins