Adult Dosing

Allergic conjunctivitis

• 1-2 gtts in each eye bid

Note:

• Continue treatment throughout the period of exposure, even in the absence of symptoms

Pediatric Dosing

• Safety and effectiveness in pediatric patients <3 yrs have not been established

Allergic conjunctivitis

• >3 yrs
• 1-2 gtts in each eye bid

Note:

• Continue treatment throughout the period of exposure, even in the absence of symptoms

• Treatment of itching associated with allergic conjunctivitis

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment:

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Patients should refrain from wearing contact lenses while exhibiting the signs and symptoms of allergic conjunctivitis
• Do not touch the tip of the dispensing container to the eye or surrounding areas in order to avoid contamination; serious damage to the eye and subsequent vision loss may result from using contaminated solutions

Supplemental Patient Information

• Advise patients not to touch the tip of the dispensing container to the eye or surrounding structures, as it may contaminate solution
• Instruct patients not to wear contact lenses during therapy

Pregnancy Category:B

Breastfeeding: No published data is available on the use of nedocromil during lactation; however, maternal milk levels are likely to be very low and it is expected to be poorly absorbed from the infant's GI tract. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 29 April 2011). Manufacturer advises caution.

• CNS: Headache
• EENT: Ocular burning, irritation and stinging, nasal congestion, conjunctivitis, eye redness, photophobia, rhinitis
• GI: Unpleasant taste
• RESP: Asthma

• Mast cell stabilizer; inhibits release of mediators from cells involved in hypersensitivity reactions, and also decreases chemotaxis and activation of eosinophils
• <4% systemic absorption
• Metabolism: None
• Excretion: Primarily unchanged in urine 70% and feces 30%
• Half-life: 3.3 hrs

US Trade Name(s)

• Alocril

US Availability

nedocromil (generic)

• OPTH SOLN: 2%

Alocril

• OPTH SOLN: 2%

Canadian Trade Name(s)

• Alocril

Canadian Availability

Alocril

• OPTH SOLN: 2%

UK Trade Name(s)

• Rapitil Eye Drops

UK Availability

Rapitil Eye Drops

• OPTH SOLN: 2%

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

Ophthalmic

Ophthalmic Antihistamines

Mast Cell Stabilizer

Allergy & Immunology

Ophthalmic Antihistamines

Mast Cell Stabilizer

Pricing data from www.DrugStore.com in U.S.A.

• Alocril 2 % SOLN [Bottle] (ALLERGAN)
  5 % = $104.99
  15 % = $304.48

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.