Adult Dosing

Bronchospasm

• 0.5 mL NEB q3-4h

Pediatric Dosing

Bronchospasm

• Greater than 4 years: 0.5 mL NEB q3-4h

Croup [Non-FDA Approved]

• Using 2.25% solution, 0.05 mL/kg/dose up to a maximum dose of 0.5 mL/dose diluted to 3 mL with 0.9% saline. Given via nebulizer over 15 min PRN but not more frequently than q1-2 hr
• It is important to note that nebulized epinephrine may need to be administered significantly more frequently than the recommended intervals in severe/critical cases

• Bronchospasm

• Hypersensitivity to any of the ingredients of the product or hypersensitivity to sulfites

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Monitor patient's respiratory status during each treatment. If bronchospasm worsens during a treatment, discontinue the treatment
• Administer drug with caution as syncope has occurred in asthmatic children
• Do not use when maternal BP exceeds 130/80 mm Hg because it may delay second stage or induce uterine atony
• During therapy tissue necrosis may develop if extravasation occurs
• Therapy may cause fatalities because of peripheral constriction or cardiac stimulation
• Excessive use may lead to tolerance and paradoxical bronchospasm

Cautions: Use cautiously in

• Cardiac disease (angina, tachycardia, MI)
• Hypertension
• Hyperthyroidism
• Diabetes
• Cerebral arteriosclerosis
• Elderly patients

Pregnancy Category:C

Breastfeeding: Probably safe. It is unlikely to interfere with breastfeeding. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 24 December 2010).

• CV: Arrhythmias, tachycardia
• RESP: Paradoxical bronchospasm
• CNS: Nervousness, insomnia, headache, dizziness, tremor
• GI: Nausea, loss of appetite

• Adrenergic; reduces mucosal secretions and relaxes bronchial smooth muscles (sympathomimetic) by stimulating alpha and beta adrenergic receptors
• Minimal systemic absorption
• Metabolized by liver
• Excreted in urine (unchanged)
• Half-life: Unknown

US Trade Name(s)

• S2

US Availability

epinephrine (generic)

• NEB: 2.25% solution

Canadian Trade Name(s)

• S2

Canadian Availability

S2

• NEB: 22.5 mg / mL

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

Pulmonary

Bronchodilators

Adrenergic Agonists

Pricing data from www.DrugStore.com in U.S.A.

• S2 2.25 % NEBU [Plas Cont] (NEPHRON PHARMACEUTICALS CORP.)
  30 % = $49.99
  60 % = $86.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.