Postexposure prophylaxis - blood exposure
- 0.06 mL/kg IM x 1; administer as soon as possible after exposure and within 24 hours if possible
- See manufactures recommendation for appropriate doses of unvaccinated and vaccinated persons and sources of potential contamination
Postexposure prophylaxis - sexual exposure to HBsAg-positive persons
- 0.06 mL/kg IM x 1; administer within 14 days of the last sexual contact or if sexual contact with the infected person will continue
Prevention of hepatitis B recurrence following liver transplantation (Only HepaGam B)
- Administer 20,000 IU IV per dose designed to attain serum levels of HBsAb >500 IU/L; administer first dose concurrently w/grafting of transplanted liver, then qd x7 d, then q2wk 2-12 wk
- Adjust dose based on anti-HBs antibody levels w/in 7 days post-transplant; give 10,000 units IV q6h until target anti-HBs antibody levels reached in pts w/ surgical bleeding, abdominal fluid drainage >500 mL, or who undergo plasmapheresis
Postexposure prophylaxis - perinatal exposure of infants born to HBsAg positive mothers with or without HBeAg
- 0.5 mL IM x 1; administer after physiologic stabilization of the infant and preferably within 12 hours of birth
- Recommended schedule of Hepatitis B immunoprophylaxis to prevent perinatal transmission, a second and third vaccination should be given at 1 month and 6 months, respectively
Postexposure prophylaxis - household exposure
- (Child < 12 months): 0.5 mL IM
- (Child > 12 months): 0.06 mL/kg IM; administer within 14 days exposure
Postexposure prophylaxis - blood exposure
- 0.06 mL/kg IM x 1; administer as soon as possible after exposure and within 24 hours if possible
