section name header

Interacting Drugs

OBJECT DRUGS

Antidepressants, Tricyclic:

PRECIPITANT DRUGS

Enzyme Inducers:


Comment:

Enzyme inducers may gradually reduce the serum levels and effect of imipramine, desipramine, amitriptyline, and probably other tricyclic antidepressants (TCA). TCAs differ in their metabolism by CYP450 isozymes; hence, the magnitude of TCAs interaction with enzyme inducers may vary as well.


Class 3: Assess Risk & Take Action if Necessary