Adult Dosing
Multiple vitamin deficiencies
M.V.I Adult and Infuvite Adult
- 5 mL of 'Vial 1' plus 5 mL of 'Vial 2' IV daily, dilute in not less then 500 mL of dextrose, saline or similar infusion
M.V.I-12 (without vitamin K)
- 10 mL two chambered vial IV daily, dilute in not less then 500 mL of dextrose, saline or similar infusion
Note:
- Do not administer as undiluted IV injection as it may give rise to dizziness, faintness and possible tissue irritation
Pediatric Dosing
Multiple vitamin deficiencies
Infuvite Adult, Infuvite Adult, M.V.I Adult (>11 yrs)
- 5 mL of 'Vial 1' plus 5 mL of 'Vial 2' IV daily, dilute in not less then 500 of dextrose, saline or similar infusion
M.V.I-12 (without vitamin K) (>11 yrs)
- 10 mL two chambered vial IV daily, dilute in not less then 500 mL of dextrose, saline or similar infusion
Infuvite pediatric (<11 yrs)
3kg up to 11 yrs: 4 mL of 'Vial 1' plus 1 mL of 'Vial 2' IV daily, dilute in not less than 100 mL of dextrose, saline or similar infusion- 1 kg-<3 kg: 65% of Vial 1 and Vial 2 IV daily, do not exceed this daily dose
- < 1 kg: 30% of Vial 1 and Vial 2 IV daily, do not exceed this daily dose
M.V.I pediatric (<11 yrs)
- Reconstitute in 5 mL of Sterile Water for Injection USP, Dextrose Injection USP 5%, or Sodium Chloride Injection
- 3kg up to 11 yrs: 5 mL IV daily, dilute in not less than 100 mL of dextrose, saline or similar infusion
- 1 kg-<3 kg: 65% of single full dose IV daily, do not exceed this daily dose
- < 1 kg: 30% of single full dose IV daily, do not exceed this daily dose
Note: - Administer supplemental vitamin A for low-birth-weight infants
- Do not administer as undiluted IV injection as it may give rise to dizziness, faintness and possible tissue irritation
[Outline]
- Parenteral multivitamin contains aluminum that may be toxic. Prolonged use can lead to toxic levels of aluminum in patients with impaired kidney function, especially premature infants
- Central nervous system and bone toxicities are associated with toxic levels of aluminum in patients with impaired kidney function, including premature neonates receiving parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day. Tissue loading may occur at even lower rates of administration
- Use cautiously in patients receiving warfarin sodium-type anticoagulant, as vitamin K may antagonize the hypoprothrombinemic response to anticoagulant drugs. Monitor prothrombin time/INR response periodically to determine the appropriate dosage of anticoagulant therapy
- Monitor blood vitamin concentrations, particularly vitamins A, C, D, and folic acid, in patients receiving parenteral multivitamins to determine if vitamin deficiencies or excesses are developing
- Long-standing specific vitamin deficiencies may require additional therapeutic amounts of specific vitamins
- Larger doses or supplementation with oral or parenteral vitamin E are not recommended in infants as adequate blood levels of vitamin E are achieved when parenteral multivitamins (M.V.I. Pediatric, Infuvite Pediatric) are given to infants at the recommended dosage
- Vitamin A may adhere to polyvinyl chloride plastic resulting in a lower vitamin A concentration in the therapeutic dose. Hence monitor blood vitamin concentrations periodically and administer additional doses of vitamin A as required
- Do not add the therapy directly to intravenous fat emulsions
- Intravenous administration of thiamine may cause allergic reactions such as urticaria, periorbital or digital edema
- Do not administer the therapy to patients with suspected/diagnosed megaloblastic anemia prior to blood sampling for the detection of the folic acid and cyanocobalamin deficiencies
- Use cautiously in patients with renal failure receiving 1.5 mg/day retinol and in those with liver disease, as it may show manifestations of hypervitaminosis A including nausea, vomiting, headache, dizziness, and blurred vision
- Vitamin C in urine may cause false negative urine glucose determination
- Use aseptic measures while administering multivitamin infusion
Cautions: Use cautiously in
- Renal impairment
- Premature infants
- Warfarin sodium-type anticoagulant therapy
Pregnancy Category:C (Infuvite Adult)
Breastfeeding: Lactating women should follow the U.S. Recommended Daily Allowances for their condition, because their vitamin requirement may exceed those of nonlactating women.
US Trade Name(s)
- Infuvite Adult
- Infuvite pediatric
- M.V.I Adult
- M.V.I Pediatric
- M.V.I-12 (without vitamin K)
US Availability
Infuvite Adult, M.V.I-12 (without vitamin K)
- INJ: 5 mL (2 vials labeled vial 1 and vial 2)
Infuvite pediatric
- INJ: 4 mL (vial 1) and 1 mL (vial 2)
- INJ: 40 mL (vial 1) and 10 mL (vial 2) [Pharmacy bulk package]
M.V.I Adult
- INJ: 5 mL (2 vials labeled vial 1 and vial 2)
M.V.I pediatric
Canadian Trade Name(s)
- Multi 12 Injection
- Multi-11
Canadian Availability
Multi 12 Injection
- INJ: 5 mL (2 vials labeled vial 1 and vial 2)
- INJ: 25 mL (2 vials labeled vial 1 and vial 2) [Pharmacy bulk pack]
Multi-11
- INJ: 5 mL (2 vials labeled vial 1 and vial 2)
UK Trade Name(s)
- Pabrinex Intramuscular High Potency Injection
- Pabrinex Intravenous High Potency Injection
UK Availability
Pabrinex Intramuscular High Potency Injection
- INJ: 5 mL (amp 1) and 2 mL (amp 2)
Pabrinex Intravenous High Potency Injection
Australian Trade Name(s)
- Cernevit
- B-Dose
- B-Dose Forte
- Soluvit N
- Vitalipid N Adult
- Vitalipid N Infants
Australian Availability
Cernevit, Soluvit N
- POWDR for INJ: Single use vial
B-Dose
B-Dose Forte
Vitalipid N Adult, Vitalipid N Infants
[Outline]