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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Enzyme Inhibitors:


Comment:

Ranolazine is metabolized primarily by CYP3A4, and inhibitors of this isozyme increase the serum concentrations of ranolazine. Theoretically, such drugs could increase the risk of ranolazine-induced QTc prolongation and ventricular arrhythmias. The product information states that ranolazine is contraindicated with potent CYP3A4 inhibitors. Because amiodarone inhibits CYP3A4 and also intrinsically prolongs the QTc interval, it would be wise to avoid combining it with ranolazine (Class 1) .


Class 2: Use Only if Benefit Felt to Outweigh Risk