Adult Dosing
Relief of common cold/flu symptoms
Coricidin HBP Nighttime Multi-Symptom Cold, Tylenol Cough & Sore Throat Nighttime
- 1000 mg/30 mg/12.5 mg PO q6hrs PRN
- Max: [4000 mg/120 mg/50 mg]/24 hrs
Vicks NyQuil Cold & Flu Nighttime Relief, Delsym Night Time Multi-Symptom, Vicks Nature Fusion Cold & Flu Nighttime Relief
- Oral Liquid
- 650 mg/30 mg/12.5 mg PO q6h PRN
- Max: [2600 mg/120 mg/50 mg]/24 hrs
- LiquCaps
- 650 mg/30 mg/12.5 mg PO q6h PRN with water
- Max: [2600 mg/120 mg/50 mg]/24 hrs
Pediatric Dosing
Relief of common cold/flu symptoms
Coricidin HBP Nighttime Multi-Symptom Cold, Tylenol Cough & Sore Throat Nighttime
- Children>12 yrs: 1000 mg/30 mg/12.5 mg PO q6hrs PRN
- Max: [4000 mg/120 mg/50 mg]/24 hrs
- <12 yrs: Consult a physician before use
Vicks NyQuil Cold & Flu Nighttime Relief, Delsym Night Time Multi-Symptom, Vicks Nature Fusion Cold & Flu Nighttime Relief
- Oral Liquid
- Children >12 yrs: 650 mg/30 mg/12.5 mg PO q6h PRN
- Max: [2600 mg/120 mg/50 mg]/24 hrs
- 4 to <12 yrs: Consult a physician before use
- <4 yrs: Do not use
- LiquiCaps
- >12 yrs: 650 mg/30 mg/12.5 mg PO q6h PRN with water
- Max: [2600 mg/120 mg/50 mg]/24 hrs
- 4 to <12 yrs: Consult a physician before use
- <4 yrs: Do not use
[Outline]
Renal Dose Adjustment (Based on CrCl)
- Acetaminophen
- 10-50 mL/min: give q6 hrs
- <10 mL/min: give q8 hrs
- Dextromethorphan/doxylamine
- Renal impairment: Dose adjustments not defined
Hepatic Dose Adjustment
- Acetaminophen
- Hepatic impairment: Consider dose reduction; dose adjustments not defined
- Dextromethorphan/doxylamine
- Hepatic impairment: Dose adjustments not defined
See Supplemental Patient Information
- Over-dosage of this product may cause severe liver damage; severe liver damage may occur on exceeding recommended dosages, concomitant use with other drugs containing acetaminophen, or on consuming 3 or more alcoholic drinks every day while receiving therapy. Avoid concomitant use with any other drugs containing acetaminophen
- In case of overdose, seek medical attention or contact a Poison Control Center immediately
- Avoid therapy in patients receiving a prescription MAOI or for 2 weeks after stopping the MAOI drug
- Excitability and marked drowsiness may occur during therapy, especially in children
- Discontinue therapy if sore throat becomes severe, persists for more than 2 days, or is accompanied or followed by fever, headache, rash, nausea, or vomiting; further evaluate the patient and provide appropriate therapy
- Discontinue therapy and consult a clinician if new symptoms occur, redness or swelling is noted, pain/cough gets worse or lasts more than 7 days, fever gets worse or lasts >3 days, or if cough comes back or occurs with rash or headache that lasts; further evaluate the patients as these could be signs of a serious condition
- Advise patients to consult a doctor or pharmacist before use of therapy if being treated with sedatives, tranquilizers, or blood thinning drugs like warfarin
- Dizziness, drowsiness, or blurred vision may occur with this drug; concomitant use of other sedatives and tranquilizers and alcohol abuse worsen these effects. Hence, avoid use of these drugs and advise patients to avoid alcohol during therapy
- Advise patients to avoid driving a motor vehicle or operating machinery during therapy, as drowsiness may occur with this product
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- Angle-closure glaucoma
- PKU (phenylalanine-containing forms)
- Chronic cough such as occurs with smoking or emphysema
- Cough with excessive phlegm
- Prostatic hypertrophy
- Sodium-restricted diet
- Geriatric patients
Supplemental Patient Information
- Advise patients to keep this drug out of the reach of children
- Instruct patients not to exceed recommended dosage
- Advise patients to avoid driving a motor vehicle or operating machinery during therapy, as drowsiness may occur with this product
- Advise patients to consult their physician if symptoms do not improve in 7 days, if new symptoms occur, or if fever gets worse or lasts more than 3 days
- Instruct patients to avoid alcoholic beverages during therapy
Pregnancy Category:B (acetaminophen), C (dextromethorphan), B (doxylamine)
Breastfeeding: Acetaminophen is a good choice for analgesia and fever reduction in nursing mothers. Amounts excreted in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare. Dextromethorphan: No studies conducted on the excretion of dextromethorphan in milk or its effect on breastfed infants. However, this medication can be administered to infants as young as 1 month of age. It is unlikely that with usual maternal doses amounts in milk are as large as those given directly to infants or that breastfed infants would be harmed by the drug in breastmilk, especially in infants over 1 month of age. Avoid the use of products with a high alcohol content while nursing. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 02 September 2011). Acetaminophen: Maternal medication is usually compatible with breastfeeding; no observable change was seen in the nursing infant while the mother was ingesting the compound. This information is based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776/T6 last accessed 02 September 2011). Manufacturer advises to consult a health professional.
US Trade Name(s)
- Coricidin HBP Nighttime Multi-Symptom Cold
- Tylenol Cough & Sore Throat Nighttime
- Vicks NyQuil Cold & Flu Nighttime Relief
- Delsym Night Time Multi-Symptom
- Vicks Nature Fusion Cold & Flu Nighttime Relief
US Availability
Coricidin HBP Nighttime Multi-Symptom Cold, Tylenol Cough & Sore Throat Nighttime (acetaminophen/dextromethorphan/doxylamine)
- OTC LIQ: [500 mg/15 mg/6.25 mg]/15 mL
Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen/dextromethorphan/doxylamine)
- OTC CAPS: 325 mg/15 mg/6.25 mg
- OTC LIQ: [325 mg/15 mg/6.25 mg]/15 mL
Delsym Night Time Multi-Symptom (acetaminophen/dextromethorphan/doxylamine)
- OTC LIQ: [325 mg/15 mg/6.25 mg]/15 mL
Vicks Nature Fusion Cold & Flu Nighttime Relief (acetaminophen/dextromethorphan/doxylamine)
- OTC LIQ: [650 mg/30 mg/7.5 mg]/30 mL
Canadian Trade Name(s)
- Cold/Flu Medicine
- Vicks NyQuil Liquicaps Cold and Flu Multi-Symptom Relief
- Vicks NyQuil Cold and Flu
- Nighttime Cold & Flu Relief
Canadian Availability
Cold/Flu Medicine, Vicks NyQuil Cold and Flu, Nighttime Cold & Flu Relief (acetaminophen/dextromethorphan/doxylamine)
- OTC LIQ: [1000 mg/30 mg/12.5 mg]/30 mL
Vicks NyQuil Liquicaps Cold and Flu Multi-Symptom Relief (acetaminophen/dextromethorphan/doxylamine)
- OTC CAPS: 325 mg/15 mg/6.25 mg
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
Australian Availability
[Outline]