Adult Dosing

Red back spider bite envenoming

• Administer 500 U IM x1 when there is evidence of severe local and/or systemic envenoming

Note:

• Give by IV route in case of life-threatening envenoming by diluting the antivenom 1:10 in Hartmann’s Solution

Pediatric Dosing

Red back spider bite envenoming

• Administer 500 U IM x1 when there is evidence of severe local and/or systemic envenoming

Note:

• Give by IV route in case of life-threatening envenoming by diluting the antivenom 1:10 in Hartmann’s Solution

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of patients who exhibit manifestations of systemic envenoming following a bite by a red back spider (Latrodectus hasselti)

• Hypersensitivity to any of the ingredients of the product
• Instances where there is no clear evidence of systemic envenoming with the potential for serious toxic effects

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Therapy may cause infectious diseases due to the transmission of infective agents. Physicians must remain alert to this possibility and communicate the same to the patients
• Therapy may cause severe allergic reactions, including anaphylactic shock in patients who are atopic or who have previously received horse serum. A syringe already loaded with 1:1000 adrenaline must be available during antivenom therapy
• Suspend therapy if anaphylaxis occurs and inject 0.3-0.5 mL of 1:1000 adrenaline subcutaneously (0.01 mL/kg in children); may repeat after 2-3 minutes if required. In severe cases, IV antihistamines and corticosteroids may be given to reduce the chance of late reactions
• Patients with severe systemic envenoming must be handled in an ICU
• Local effects of envenomation such as severe pain, erythema, swelling and sweating may occur in the first hour; severe systemic effects may not occur until 12 hours after envenoming
• Delayed serum sickness manifested by fever, cutaneous eruptions, arthralgia, lymphadenopathy, and albuminuria has been reported with use of animal-derived antivenoms. Such reaction may appear 8-13 days after antivenom use, but can occur as early as 12 hrs following a second injection of a similar animal protein

Pregnancy Category:NR

Breastfeeding: Safety unknown.

• NEURO: Neuropathy
• CV: Vasculitis
• HEMA: Lymphadenopathy
• IMMU: Allergic reactions, anaphylactic reactions, anaphylactic shock, delayed serum sickness
• METABOLIC: Albuminuria
• GU: Nephritis
• DERM: Urticaria, rash, cutaneous eruptions
• MUSC: Arthralgia, arthritis
• LOCAL: Injection site reactions, severe pain, erythema, swelling, sweating
• MISC: Pyrexia, chest pain

• Antivenom; contains specific antibodies against the toxic substances in the venom of the red back spider
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• N/A

US Availability

• N/A

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Only generic available

Australian Availability

antivenom red back spider (generic)

• INJ: 500 U/vial

[Outline]

Emergency/Critical Care

Antivenins

Spider