Adult Dosing

Iron deficiency anemia

• Patients weighing =>50 kg: 750 mg IV once, follow 7 days later with second 750 mg dose; not to exceed cumulative dose of 1,500 mg per course
• Patients weighing <50 kg: 15 mg/kg IV once, follow 7 days later with second dose; not to exceed 1500 cumulative dose per course
• Given as slow IV push, 100 mg (2 ml) per minute or infusion with 0.9% NaCl Solution diluted to 2 - 4 mg/ml

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of iron deficiency anemia in adult patients who have intolerance to oral iron or have had unsatisfactory response to oral iron and patients who have non-dialysis dependent chronic kidney disease

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving therapy. Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse
• Closely monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion
• Hypertension, transient elevations in systolic blood pressure, sometimes occurring with facial flushing, dizziness, or nausea have been assocaited with therapy

Pregnancy Category:C

Breastfeeding: It is unknown whether this drug is excreted in human breast milk. Manufacturer advises caution.

• CNS: Dizziness, headache
• GI: Nausea, vomiting, dysgeusia, constipation
• CV: Hypertension, hypotension
• LAB TESTS: Alanine aminotransferase increase, blood phosphorus decrease

• Colloidal iron (III) hydroxide in complex with carboxymaltose; a carbohydrate polymer that releases iron; replaces iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: 7-12 hrs

US Trade Name(s)

• Injectafer

US Availability

Injectafer

• INJ: 50 mg /15 mL

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• Ferinject

UK Availability

Ferinject

• INJ: 50 mg /mL

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Nutrition/Electrolytes

Iron Products