- Dose of obinutuzumab is administered during 6 treatment cycles each of 28 days duration, as an IV infusion, through a dedicated line
- Do not administer as a IV push or bolus
- Cycle 1
- Day 1: 100 mg IV . Administer at 25 mg/hr over 4 hours. Do not increase the infusion rate
- Day 2: 900 mg IV. Administer at 50 mg/hr. The rate of the infusion can be escalated in increments of 50 mg/hr every 30 minutes to a maximum rate of 400 mg/hr
- Day 8 and Day 15: 1,000 mg IV: Start infusion at a rate of 100 mg/hr and increased by 100 mg/hr increments every 30 minutes to a maximum of 400 mg/hr
- Cycles 2-6
- Day 1: 1,000 mg IV: Start infusion at a rate of 100 mg/hr and increased by 100 mg/hr increments every 30 minutes to a maximum of 400 mg/hr
Note:
- Premedicate with glucocorticoid, acetaminophen and anti-histamine, before each infusion to reduce the risk of infusion reactions (Refer package insert for detail information of premedication infusion, preparation and administration procedure)
- In case if dose is missed, administer the missed dose as soon as possible and adjust dosing schedule accordingly. If appropriate, patients who do not complete the Day 1 Cycle 1 dose may proceed to the Day 2 Cycle 1 dose
- Should be administer only as an intravenous infusion through a dedicated line
- Monitor blood counts at regular intervals
- Safety and effectiveness have not been established in pediatric patients
