Adult Dosing
Diagnosis of known or suspected growth hormone deficiency
- 30 g (300 mL) IV over 30 minutes
- Max: 30 g/dose
Pediatric Dosing
Diagnosis of known or suspected growth hormone deficiency
59 kg: 0.5 g/kg (5 mL/kg) IV over 30 minutes- >60 kg: 30 g (300 mL) IV over 30 minutes
- Max: 30 g/dose
[Outline]
- Overdosage of arginine can cause hyperchloremic metabolic acidosis, cerebral edema or death in pediatric patients, hence use with extreme caution in pediatric patients
- Arginine can cause hypersensitivity reactions including anaphylaxis, institute appropriate medical support if serious hypersensitivity reaction occurs
- It is for diagnostic aid only and is not intended for therapeutic use
- Because of its hypertonicity and acidic nature, it should always be administered by intravenous infusion, as it can cause irritation and damage to tissues
- Arginine can be metabolized, resulting in nitrogen-containing compounds for excretion. Consider the effect of an acute amino acid or nitrogen burden upon patients with impaired renal function
- Inadequate dosing or prolong infusion period can diminish the stimulus to the pituitary and nullify the test
- Elevates basal and post stimulation levels of growth hormone in patients who are pregnant or are taking oral contraceptives
- This product contains chloride (47.5 mEq/100 mL of solution), evaluate the effect of infusing this amount of chloride into patients with electrolyte imbalance before the test is undertaken
Cautions: Use cautiously in
- Renal impairment
- Electrolyte imbalance
- Pediatric patients
Pregnancy Category:B
Breastfeeding: Systemically administered amino acid is secreted in to breastmilk but not likely to have an adverse effect on the infant. It is unknown whether excreted in breastmilk after IV administration. However manufacturer advises caution while administering nursing mothers.
Pricing data from www.DrugStore.com in U.S.A.
- Arginine 500 MG TABS [Bottle] (MAJOR PHARMACEUTICALS)
30 mg = $12.99
90 mg = $38.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
