Adult Dosing

Premature ovulation prevention

• 0.25 mg SC once daily during the mid-to-late follicular phase of menstrual cycle after initiating FSH on day 2 or 3 of cycle; continue daily until day of administration of human chorionic gonadotropin (when adequate follicular response achieved)

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation

• Hypersensitivity to any of the ingredients of the product
• Hypersensitivity to gonadotropin releasing hormone or any of its analogs
• Pregnancy

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Administer therapy under supervision of physicians who are experienced in infertility treatment
• Pregnancy must be excluded prior to initiating therapy
• May cause hypersensitivity reactions with the first dose, including anaphylactoid reactions

Supplemental Patient Information

• Prior to initiating the therapy, patients should be informed of the duration of treatment and monitoring procedures that will be required
• Therapy should not be prescribed if the patient is pregnant

Pregnancy Category:X

Breastfeeding: Safety unknown. According to manufacturer data it should not be used by lactating women.

• CNS: Headache
• GI: Abdominal pain, nausea
• REPRODUCTIVE: Ovarian hyperstimulation syndrome, fetal death
• GU: Pelvic pain, vaginal bleeding
• LOCAL: Injection site reactions

• Gonadotropin-releasing hormone antagonist; suppresses surges in LH by inducing a rapid, reversible suppression of gonadotropin
• Well absorbed following SC administration
• Metabolism: Unknown
• Excreted in urine

US Trade Name(s)

• Only generic available

US Availability

ganirelix (generic)

• INJ (prefilled syringes): 0.25 mg/0.5 mL

Canadian Trade Name(s)

• Orgalutron

Canadian Availability

Orgalutron

• INJ (prefilled syringes): 0.25 mg/0.5 mL

UK Trade Name(s)

• Orgalutron

UK Availability

Orgalutron

• INJ (prefilled syringes): 0.25 mg/0.5 mL

Australian Trade Name(s)

• Orgalutron

Australian Availability

Orgalutron

• INJ (prefilled syringes): 0.25 mg/0.5 mL

[Outline]

Endocrine/Metabolic

Sex Hormones

Gonadotropin Releasing Hormones Antagonists

Obstetrics/Gynecology

Sex Hormones

Gonadotropin Releasing Hormones Antagonists

Pricing data from www.DrugStore.com in U.S.A.

• Ganirelix Acetate 250 MCG/0.5ML SOLN [Syringe] (ORGANON)
  0.5 0.5ml = $130.98
  1.5 0.5ml = $379.1

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.