Adult Dosing

• Adult Dosing not applicable

Pediatric Dosing

• Safety and effectiveness in infants <4 weeks of age (premature or term) has not been established

Diaper dermatitis

• Gently apply a thin layer to the affected area at each diaper change X 7 days

Note:

• Continue treatment for complete 7 days, even if there is improvement
• Do not continue treatment beyond 7 days
• Do not rub into the skin as it may result in irritation

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of diaper dermatitis when complicated by documented candidiasis in immunocompetent pediatric patients 4 weeks

Note:

• Not to be used as a substitute for frequent diaper changes
• Not to be used as a prophylactic for diaper dermatitis, due risk of drug resistance

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Not for oral, ophthalmic, or intravaginal use
• Instruct patients to discontinue therapy and seek prompt medical attention if irritation occurs or if the condition worsens
• Safety and efficacy of the combination drug has not been evaluated in incontinent adult patients using diapers
• Not indicated for use as a prophylactic for diaper dermatitis, such as in an adult institutional setting, due risk of development of drug resistance

Pregnancy Category:C

Breastfeeding: In its unknown if any of the drug components are excreted in breast milk. Manufacturer advises caution.

Post-marketing events

• GI: Vomiting
• DERM: Blister, dermatitis contact, diaper dermatitis, dry skin, erythema, pruritus, rash, skin exfoliation
• LOCAL: Burning sensation, condition aggravated, inflammation, pain
• MISC: Accidental exposure

Miconazole

• Antifungal; precise mechanism of action unknown; inhibits 14-alpha demethylase, reduces fungal cell membrane ergosterol synthesis and increases cellular permeability
• Minimal systemic absorbtion
• Not metabolized; CYP450: None
• Excretion: None
• Half-life: Unknown

Petrolatum

• Skin protectant; forms a protective layer on skin to immediately soothe, acts as a temporary barrier over exposed tissues, maintains moisture and protects from external irritants
• Absorption: Minimal systemic absorption
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

Zinc oxide

• Skin protectant; provides protective barrier over exposed tissues, protecting from external irritants; enhances re-epithelialization, reduces inflammation, and decreases bacterial growth in injured skin
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• Vusion

US Availability

Vusion (miconazole/petrolatum/zinc oxide)

• OINT: 0.25%/81.35%/15% (50 g tube)

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Dermatologic

Dermatologic Topical Agents

Antifungals/skin Protectant Combination

Pricing data from www.DrugStore.com in U.S.A.

• Vusion 0.25-15-81.35 % OINT [Tube] (GLAXO SMITH KLINE)
  50 % = $265.99
  150 % = $756.01

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.