Adult Dosing

Impetigo

• Apply 2% ointment tid daily for 10 days. If no response in 3-5 days reevaluate

Note:

• Applied for impetigo caused by S.aureus or S.pyogenes

Skin infections

• Apply 2% cream tid daily for 10 days

Pediatric Dosing

Impetigo

• >2 months
• Apply 2% ointment tid daily for 10 days. If no response in 3-5 days reevaluate

Note:

• Applied for impetigo caused by S.aureus or S.pyogenes

Skin infections

• >2 months
• Apply 2% cream tid daily for 10 days

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of impetigo
• Treatment of secondarily infected traumatic skin lesions (Bactroban cream)

• Hypersensitivity to any of the ingredients of the product
• Ophthalmic use
• Large open wounds (ointment)

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Not for ophthalmic use
• Sensitivity or chemical irritation may occur with the use of mupirocin; if such reactions occur discontinue the treatment and give alternative therapy for the infection instituted
• Overgrowth of nonsusceptible organisms, including fungi may occur with long-term therapy
• Avoid using treatment in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment

Supplemental Patient Information

• For external use only
• Avoid contact with the eyes
• Treated area may be covered by gauze dressing if required

Pregnancy Category:B

Breastfeeding: Since <1% is absorbed after topical application, mupirocin is considered a low risk to the nursing infant. Ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible creams should be applied to the breast. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 14 April 2011).Manufacturer advises caution.

• CNS: Headache
• GI: Nausea
• DERM: Burning, stinging, itching, pruritus, erythema, dry skin, cellulitis
• LOCAL: Application site reactions
• MISC: Pain, tenderness, superinfection

• Antibiotic agent; inhibits bacterial protein synthesis
• Minimal systemic absorption following topical administration
• Metabolized by liver
• Renally excreted
• Half-life: 20-40 minutes

US Trade Name(s)

• Bactroban
• Centany

US Availability

mupirocin (generic)

• OINT: 2%
• CRE: 2%

Bactroban

• CRE: 2%
• OINT: 2%

Centany

• OINT: 2%

Canadian Trade Name(s)

• Bactroban

Canadian Availability

mupirocin (generic)

• OINT: 2%

Bactroban

• CRE: 2%
• OINT: 2%

UK Trade Name(s)

• Bactroban

UK Availability

Bactroban

• CRE: 2%
• OINT: 2%

Australian Trade Name(s)

• Bactroban

Australian Availability

Bactroban

• CRE: 2%
• OINT: 2%

[Outline]

Antimicrobials

Dermatologic Topical Agents

Antibiotics

Infectious Disease

Dermatologic Topical Agents

Antibiotics

Dermatologic

Dermatologic Topical Agents

Antibiotics

Pricing data from www.DrugStore.com in U.S.A.

• Bactroban 2 % OINT [Tube] (GLAXO SMITH KLINE)
  22 % = $79.99
  66 % = $219.98
• Bactroban 2 % CREA [Tube] (GLAXO SMITH KLINE)
  30 % = $96.99
  90 % = $280.98
• Bactroban 2 % CREA [Tube] (GLAXO SMITH KLINE)
  15 % = $64.99
  45 % = $181.96
• Mupirocin 2 % OINT [Tube] (PERRIGO PHARMACEUTICALS)
  22 % = $37.99
  66 % = $98.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.