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Use and Dosing

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Complex Partial Seizures

Monotherapy (Initial Therapy)

Conversion to Monotherapy

Adjunctive Therapy

Simple and Complex Absence Seizures

Note:

Status Epilepticus [Non-FDA Approved]@

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Complex Partial Seizures (gteq.gif10 yrs)

Monotherapy

Conversion to Monotherapy (gteq.gif10 yrs)

Adjunctive Therapy (gteq.gif10 yrs)

Simple and Complex Absence Seizures (gteq.gif10 yrs)

Note:

Status Epilepticus [Non-FDA Approved]@


[Outline]

Indications

Note:

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in

Supplemental Patient Information

Pregnancy/Breast Feeding

Pregnancy Category:D

Breastfeeding: Low level of valproic acid is excreted in breastmilk; no unquestionable adverse reactions to valproic acid have been reported during breastfeeding. Monitoring infant serum valproate levels, platelets and liver enzymes during maternal therapy as breastfed infants are at risk for valproate induced hepatotoxicity and thrombocytopenia. Monitor infants for jaundice and other signs of liver damage, unusual bruising or bleeding. Combination therapy with sedating anticonvulsants or psychotropics may result in infant sedation or withdrawal reactions. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT) last accessed 13th December 2010). However manufacturer advises to discontinue nursing when valproate is administered to a nursing woman.

Adverse Reactions

Clinical Pharmacology

Brands and Availability

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US Trade Name(s)

US Availability

valproate sodium (generic)

Depacon

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Canadian Trade Name(s)

Canadian Availability

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UK Trade Name(s)

UK Availability

Epilim

Episenta

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Australian Trade Name(s)

Australian Availability

Epilim IV


[Outline]

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Classification

Neurologic

Anticonvulsants

Pill