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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Enzyme Inhibitors:


Comment:

Rifabutin serum concentrations can be markedly increased by CYP3A4 inhibitors; toxicity is often manifested by uveitis but rash, bone marrow suppression, and increased hepatic enzymes can also occur. Also, the plasma concentrations of some of the enzyme inhibitors listed above (e.g., cyclosporine, diltiazem, verapamil) are likely to be substantially reduced due to the ability of rifabutin to act as an enzyme inducer.


Class 2: Use Only if Benefit Felt to Outweigh Risk