Adult Dosing

Riboflavin deficiency

• 5-25 mg PO qd

Dietary supplement

• Males:
• 1.4-1.8 mg PO qd

• Females:
• 1.2-1.3 mg PO qd

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Prevention and treatment of riboflavin deficiency
• As a dietary supplement

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments
• Hemodialysis: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Take dietary supplements only under the supervision of a knowledgeable health care provider as potential for side effects and interactions with medications exist
• This drug is generally considered safe even at higher doses. Doses >10 mg/day may cause eye damage from the sun; advise patients taking higher doses to wear sunglasses that protect their eyes from ultraviolet light
• Very high doses are associated with itching, numbness, burning or prickling sensations, yellow or orange urine, and sensitivity to light
• Taking any one of the B complex vitamins individually for a longer duration may result in an imbalance of the other B vitamins. For this reason, it is generally recommended to take a B complex vitamin with any single B vitamin

Caution: Use cautiously in

• Pregnancy (Doses >RDA)

Pregnancy Category:A (C if dose >RDA)

Breastfeeding: This drug is excreted in breastmilk

• GU: Yellow-orange discoloration of urine

• Vitamin; binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase; acts as an antioxidant by playing its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione
• Absorbed from duodenum
• Metabolized in GI tract, liver; CYP450: Unknown
• Excreted in urine and small amount in bile, feces, and sweat
• Half-life: 66-84 min

US Trade Name(s)

• Only generic available

US Availability

riboflavin (generic)

• OTC TABS: 25, 50, 100 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Only generic available

Australian Availability

riboflavin (generic)

• OTC TABS: 100 mg

[Outline]

Nutrition/Electrolytes

Vitamins