section name header

Interacting Drugs

OBJECT DRUGS

Vinca Alkaloids:

PRECIPITANT DRUGS

Enzyme Inhibitors:


Comment:

Vinca alkaloids appear to be metabolized by CYP3A4 and several reports have described severe vincristine toxicity in patients receiving CYP3A4 inhibitors. P-glycoprotein inhibition may also be involved in these interactions.


Class 2: Use Only if Benefit Felt to Outweigh Risk