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Use and Dosing

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Moderate to severe pain

Notes:

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[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in:

Supplemental Patient Information

Pregnancy/Breast Feeding

Pregnancy Category:C

Breastfeeding: Oral doses of maternal morphine in the immediate postpartum period result in higher milk levels than with epidural morphine; however, these levels are quite low. It is best to limit maternal parenteral morphine dosage and to supplement analgesia with a nonnarcotic analgesic if mother's milk comes in. If the baby shows signs of increased sleepiness (more than usual), difficulty in breastfeeding, breathing difficulties, or limpness, immediately contact a physician. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 27 May 2011). Limited data indicates that naltrexone is minimally excreted in breastmilk. It is not a reason to discontinue breastfeeding, if naltrexone is required by the mother. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 27 May 2011). As per manufacturer data moephin is excreted in the maternal milk in milk to plasma ratio of 2.5:1. Withdrawal symptoms can occur in breast-feeding infants when maternal administration of morphine sulfate is stopped. Because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Adverse Reactions

Clinical Pharmacology

Morphine

Naltrexone

Brands and Availability

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US Trade Name(s)

US Availability

Embeda (morphine/naltrexone)

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Canadian Trade Name(s)

Canadian Availability

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UK Trade Name(s)

UK Availability

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Australian Trade Name(s)

Australian Availability


[Outline]

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Classification

Analgesics

Analgesic Combinations
Opioid Agonist-antagonist Combinations

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill