miconazole [Topical]

Adult Dosing

Tinea corporis

Apply to affected areas bid for 4 wks

Tinea cruris

Apply to affected areas bid for 2 wks

Tinea pedis

Apply to affected areas bid for 4 wks

Pediatric Dosing

Tinea corporis

>2 yrs: Apply to affected areas bid for 4 wks

Tinea cruris

>2 yrs: Apply to affected areas bid for 2 wks

Tinea pedis

>2 yrs: Apply to affected areas bid for 4 wks

[Outline]

Adult Dosing
Pediatric Dosing

Indications ⬆ ⬇

Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm)

Contraindications ⬆ ⬇

Hypersensitivity to any of the ingredients of the product

Black Box Warnings ⬆ ⬇

Dosing Adjustment ⬆ ⬇

Renal Dose Adjustment

Renal impairment: No dose adjustments

Hepatic Dose Adjustment

Hepatic impairment: No dose adjustments

Warnings/Precautions ⬆ ⬇

See Supplemental Patient Information

Discontinue therapy on occurrence of sensitivity or chemical irritation
Avoid using if patient has fever, pain in lower abdomen, shoulder or back
Avoid using with blood thinning agents as bleeding and bruising have occurred
Some products contain alcohol or bisulfites and should be avoided in patients with known intolerance
It may cause transient irritation, burning or stinging

Cautions: Use cautiously in

Nail infections (additional systemic therapy required)
Scalp infections (additional systemic therapy required)

Supplemental Patient Information

Advise patients to contact their clinician on development of fever, pain in lower abdomen, shoulder or back as they might be suffering from more serious disease
Advise patients to contact their clinician if symptoms do not improve after 3 days of therapy or still having symptoms after 1 wk of therapy. Also advise them to consult their clinician if symptoms return within 2 months as it may be due to diabetes, pregnancy, weakened immune system
Advise patients to contact their clinician on development of skin rash or hives

Interactions ⬆ ⬇

Desenex, Fungoid, Micatin, Neosporin AF, Zeasorb-AF interacts with :

	Acenocoumarol
	Amaryl
	Avandia
	Chlorpropamide
	Coumadin
	DiaBeta
	Diabinese
	Glimepiride
	Glipizide
	Glucotrol
	Glucotrol XL
	Glyburide
	Glynase
	Jantoven
	Nateglinide
	Orinase
	Rosiglitazone
	Starlix
	Tolbutamide
	Warfarin

Lotrimin AF interacts with :

Pregnancy/Breast Feeding ⬆ ⬇

Pregnancy Category:C

Breastfeeding: Topically applied miconazole is minimally absorbed, thus would not adversely affect the breastfed infant. Topical application, including application to the nipples is acceptable for use in nursing mothers. Wipe off excess cream before breastfeeding. This data is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 17 February 2011). Manufacturer advises caution.

Adverse Reactions ⬆ ⬇

DERM: Irritation, burning, stinging, maceration, contact dermatitis, pruritus, erythema

Clinical Pharmacology ⬆ ⬇

Antifungal; precise mechanism of action unknown; inhibits 14-alpha demethylase, reduces fungal cell membrane ergosterol synthesis and increases cellular permeability
Minimal systemic absorbtion
Not metabolized; CYP450: None
Excretion: None
Half-life: Unknown

Brands and Availability ⬆ ⬇

US Trade Name(s)

Fungoid
Lotrimin AF
Desenex
Micatin
Neosporin AF
Zeasorb-AF

US Availability

Fungoid

OTC Tincture: 2%

Lotrimin AF, Desenex

OTC PWDR: 2%
OTC SPRAY: 2%

Micatin

OTC CRE:2%

Neosporin AF

OTC CRE:2%
OTC SPRAY: 2%

Zeasorb-AF

OTC PWDR: 2%
OTC GEL: 2%

Canadian Trade Name(s)

Micatin
Monistat derm

Canadian Availability

Micatin

CRE: 2%
PWDR: 2%
SPRAY PWDR: 2%

Monistat derm

CRE: 2%

UK Trade Name(s)

Daktarin
Daktarin Aktiv

UK Availability

miconazole (generic)

CRE: 2%

Daktarin

CRE: 2%
ORAL GEL: 2%
PWDR: 2%
SPRAY PWDR (aerosol): 0.16%

Daktarin Aktiv

CRE: 2%
ORAL GEL: 2%
PWDR: 2%
SPRAY PWDR (aerosol): 0.16%

Australian Trade Name(s)

Daktarin
Eulactol
Resolve

Australian Availability