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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Antimicrobials:


Comment:

Ranolazine is metabolized primarily by CYP3A4, and inhibitors of this isozyme increase the serum concentrations of ranolazine. Theoretically, such drugs could increase the risk of ranolazine-induced QTc prolongation and ventricular arrhythmias. The product information states that ranolazine is contraindicated with potent CYP3A4 inhibitors.


Class 2: Use Only if Benefit Felt to Outweigh Risk