See Supplemental Patient Information
- Make appropriate medical support before administration as hypersensitivity reactions have been reported
- Institute emergency treatment if any hypersensitivity reaction occurs
- If infusion related reactions like headache, dizziness, hypotension, hypertension, nausea, fatigue, asthenia, apyrexia occur, manage it by slowing the infusion rate, premedicating with antihistamines, antipyretics and/or corticosteroids, and/or stopping and resuming treatment with increased infusion time
- Make dose adjustments according to therapeutic requirement
- Premedicate patients with antihistamines and/or corticosteroids to prevent subsequent reactions in symptomatic treatment
Cautions: Use cautiously in
- Hypersensitivity reactions
- Infusion-related reactions
- Elderly patients
Supplemental Patient Information
- Advise patient or caregiver that medication will be prepared and administered by a health care provider in a health care setting
- Advise Patient that velaglucerase may cause hypersensitivity reactions or infusion-related reactions
Pregnancy Category:B
Breastfeeding: Safety unknown; No data exist on the use of velaglucerase during breastfeeding. Because it is an enzyme, it is likely to be destroyed in the infant's gastrointestinal tract and not absorbed systemically. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 09 December 2010). Manufacturer advises caution while administering to nursing woman.
