Adult Dosing

Benign prostatic hyperplasia (BPH)

• 10 mg PO Daily
• Note: To be taken immediately after the same meal each day

Pediatric Dosing

• Safety and effectiveness in pediatric population have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Benign prostatic hyperplasia

• Hypersensitivity to alfuzosin or any of the components of the product
• Moderate or severe hepatic impairment (Childs-Pugh class B or C)
• Concomitant CYP3A4 inhibitors, such as ketoconazole, itraconazole, ritovavir)

• N/A

Renal Dose Adjustment

• Renal impairment: Caution advised

Hepatic Dose Adjustment

• Moderate or severe hepatic impairment (Child-Pugh Class B or C): Contraindicated

• Rule out prostatic carcinoma before starting therapy
• Postural hypotension can develop within a few hours following administration; increased risk with concomitant antihypertensives. Monitor patient for orthostatic hypotension
• Intraoperative Floppy Iris Syndrome (IFIS) has been observed during cataract surgery in some patients on or previously treated with alpha-1 blockers
• Assess changes in urinary symptoms such as hesitancy, frequency, volume, dribbling, and nocturia
• Do not use in moderate to severe hepatic impairment or severe renal impairment
• Concomitant use of potent inhibitors of the CYP3A4 enzyme system or other alpha-adrenergic blocking agents not recommended
• Discontinue if angina develops or worsens
• Monitor BP regularly

Cautions: Use cautiously in

• Severe renal impairment
• Coronary artery disease
• Congenital or acquired QTc prolongation
• Concurrent QTc prolonging agents
• Concurrent antihypertensives
• Cataract surgery

Uroxatral interacts with :

	Agenerase
	Akne-mycin
	Amiodarone
	Amprenavir
	Aprepitant
	Atazanavir
	Biaxin
	Biaxin XL
	Boceprevir
	Calan
	Calan SR
	Cardizem
	Cardizem CD
	Cardizem LA
	Cartia XT
	Ceritinib
	Cetraxal
	Ciloxan
	Cipro
	Cipro IV
	Cipro XR
	Ciprofloxacin
	Clarithromycin
	Cobicistat
	Conivaptan
	Cordarone
	Covera-HS
	Crixivan
	Cyclosporine
	Darunavir
	Delavirdine
	Diflucan
	Dilacor XR
	Dilt-CD
	Diltiazem
	Diltzac
	Dronedarone
	E-Mycin
	E.E.S.
	Emend
	Ery-Tab
	Eryc
	Erygel
	Eryped
	Erythra-Derm
	Erythro-statin
	Erythrocin
	Erythromycin
	Extina
	Fluconazole
	Gengraf
	Gleevec
	Grapefruit
	Imatinib
	Incivek
	Indinavir
	Invirase
	Isoptin
	Isoptin SR
	Itraconazole
	Juxtapid
	Ketek
	Ketoconazole
	Korlym
	Lapatinib
	Lomitapide
	Mifepristone
	Multaq
	Nelfinavir
	Neoral
	Nexterone
	Nizoral
	Nizoral A-D Shampoo
	Nizoral Shampoo
	Norvir
	Noxafil
	Onmel
	Pacerone
	PCE
	Pediamycin
	Posaconazole
	Prezista
	Proquin XR
	Quinupristin
	Rescriptor
	Restasis
	Reyataz
	Ritonavir
	Sandimmune
	Saquinavir
	Sporanox
	Stribild
	Synercid
	TAO
	Taztia XT
	Telaprevir
	Telithromycin
	Tiazac
	Troleandomycin
	Tykerb
	Vaprisol
	Veralan
	Verapamil
	Verelan PM
	Vfend
	Victrelis
	Viracept
	Voriconazole
	Xolegel
	Zykadia

Pregnancy Category:B

Breastfeeding: Safety Unknown; not indicated for use in women

• CNS: Dizziness, fatigue, headache, syncope
• EENT: Intraoperative floppy iris syndrome
• RESP: Upper respiratory tract infection, bronchitis, sinusitis, pharyngitis
• CV: Orthostatic hypotension, angina exacerbation
• EENT: Intraoperative Floppy Iris Syndrome
• GI: Abdominal pain, constipation, dyspepsia, nausea, hepatotoxicity
• GU: Erectile dysfunction, priapism
• MISC: Pain

• Alpha-1 adrenergic blocker; antagonizes alpha-1a adrenergic blockers, relaxes smooth muscles in the prostate and bladder
• Extensively metabolized by liver; CYP450: 3A4 substrate
• Bioavailability: 49%
• Renally excreted: 24% (11% unchanged); feces: 69%
• Half-life: 10 hrs

US Trade Name(s)

• Uroxatral

US Availability

alfuzosin (generic)

• ETABS: 10 mg

Uroxatral

• ETABS: 10 mg

Canadian Trade Name(s)

• Xatral

Canadian Availability

alfuzosin (generic)

• ETABS: 10 mg

Xatral

• ETABS: 10 mg

UK Trade Name(s)

• Besavar XL
• Xatral
• Xatral XL

UK Availability

alfuzosin (generic)

• TABS: 2.5 mg

Besavar XL

• ETABS: 10 mg

Xatral

• TABS: 2.5 mg

Xatral XL

• ETABS: 10 mg

Australian Trade Name(s)

• Xatral SR

Australian Availability

Xatral SR

• ETABS: 10 mg

[Outline]

Cardiovascular

Antiadrenergic Agents

Peripherally Acting

Pricing data from www.DrugStore.com in U.S.A.

• Uroxatral 10 MG TB24 [Bottle] (SANOFI-AVENTIS U.S.)
  30 mg = $142.99
  90 mg = $395.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Drug Name: 24 HR UroXatral 10 MG Extended Release Tablet

Ingredient(s): Alfuzosin

Imprint: X10

Color(s): White

Shape: Round

Size (mm): 8.00

Score: 1

Inactive Ingredient(s): N/A

Drug Label Author:
Stat Rx USA

DEA Schedule:
Non-Scheduled

Drug Name: 24 HR UroXatral 10 MG Extended Release Tablet

Ingredient(s): Alfuzosin

Imprint: X10

Color(s): White

Shape: Round

Size (mm): 8.00

Score: 1

Inactive Ingredient(s): silicon dioxide / ethylcellulose (100 cps) / hydrogenated castor oil / hypromellose / magnesium stearate / mannitol / cellulose, microcrystalline / povidone / ferric oxide yellow

Drug Label Author:
sanofi-aventis U.S. LLC

DEA Schedule:
Non-Scheduled