OBJECT DRUGS

• Flibanserin (Addyi)

PRECIPITANT DRUGS

Enzyme Inhibitors:

• Amiodarone (Cordarone, etc.)
• Amprenavir (Agenerase)
• Aprepitant (Emend)
• Atazanavir (Reyataz)
• Boceprevir (Victrelis)
• Ceritinib (Zykadia)
• Cobicistat (Stribild)
• Conivaptan (Vaprisol)
• Cyclosporine (Neoral, etc.)
• Darunavir (Prezista)
• Delavirdine (Rescriptor)
• Dronedarone (Multaq)
• Grapefruit
• Imatinib (Gleevec)
• Indinavir (Crixivan)
• Lapatinib (Tykerb)
• Lomitapide (Juxtapid)
• Mifepristone (Korlym)
• Nelfinavir (Viracept)
• Ritonavir (Norvir)
• Saquinavir (Invirase)
• Telaprevir (Incivek)

Comment:

Flibanserin is a CYP3A4 substrate, and CYP3A4 inhibitors may increase the risk of flibanserin toxicity.

Class 3: Assess Risk & Take Action if Necessary

• Consider Alternative:
• Grapefruit: Orange juice does not appear to inhibit CYP3A4.
• Monitor: If flibanserin is used with CYP3A4 inhibitors, monitor for evidence of flibanserin toxicity such as hypotension, fainting, and CNS depression. Reduce flibanserin dose as needed.