Adult Dosing
Cholecystography and cholangiography
- 20 mL IV injection, administer slowly over a 10-minute period
- Do not repeat dose for 24 hrs
Notes:- In order to remove excess intestinal gas, instruct patients to have a low residue diet on the day before examination and to administer castor oil the night before or neostigmine at the time of examination
- Examine gallbladder following 2 hrs of IV administration; patient should be returned for a 24-hr film if visualization is not achieved after 2.5 hrs
- In the presence of hepatic impairment (BSP retention >30-40%), visualization is usually not achieved because the contrast medium is not excreted efficiently by the liver. The contrast agent is excreted by the kidneys if there is a severe liver damage
Pediatric Dosing
Cholecystography and cholangiography
- 0.3-0.6 mL/kg body weight IV, administer slowly over a 10-minute period
- Do not repeat dose for 24 hrs
- Max: 20 mL
Notes:- In order to remove excess intestinal gas, instruct patients to have a low residue diet on the day before examination and to administer castor oil the night before or neostigmine at the time of examination
- Visualization of gallbladder occurs 30 minutes-4 hrs after administration
- In the presence of hepatic impairment (BSP retention >30-40%), visualization is usually not achieved because the contrast medium is not excreted efficiently by the liver. The contrast agent is excreted by the kidneys if there is a severe liver damage
- Use lowest dose
- Iodinated contrast media are not indicated for intrathecal use, as they may cause serious adverse reactions such as death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema
- Avoid using this product for epidural administration procedures such as pain management catheter placement due to the potential for inadvertent administration into the intrathecal space during epidural administrations
- Radiopaque contrast agents should be administered cautiously in patients with pheochromocytoma. Procedures may be performed if the possible benefits of such procedures outweigh the considered risks; however, the dose should be kept to an absolute minimum. Blood pressure should be assessed throughout the procedure and measures for treatment of a hypertensive crisis should be readily available
- Contrast media may produce sickling phenomenon when injected intravenously or intra-arterially in individuals who are homozygous for sickle cell disease
- Perform thyroid function tests prior to contrast agent administration as it may alter the results of thyroid function tests
- Diagnostic procedures involving use of radiopaque materials should be performed under the guidance of personnel with prerequisite training and with a thorough knowledge of the particular procedure to be performed; appropriate facilities should be readily available for coping with situations that may arise as a result of the procedure
- Therapy may cause delayed reactions after intravascular administration of a radiopaque agent; hence, emergency facilities should be available for at least 30-60 minutes following administration
- Perform a pretest to avoid severe, life-threatening reactions to radiopaque agent
- Collect urine specimen before administration of the contrast media or two or more days following administration as it may interfere with some chemical determinations made on urine specimens
- Do not mix diphenhydramine hydrochloride injection with iodipamide injection as this may cause precipitation in syringe or tubing. Administer antihistamine and iodipamide at different sites if they are to be administered concomitantly
- During the injection, monitor patients for untoward reactions such as a feeling of warmth, flushing, and nausea
Cautions: Use cautiously in
- History of sensitivity to iodine per se or to other contrast agents
- History of bronchial asthma or allergy
- Family history of allergy
- Previous reaction to a contrast agent
- Debilitated patients
- Severe hypertension
- Patients with thrombosis
Pregnancy Category:NR
Breastfeeding: IV iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally, hence are unlikely to affect breastfed infants. Guidelines developed by several professional organizations state that nursing need not be discontinued after a nursing woman receives an iodine-containing contrast medium. However, no information is available regarding iodipamide use during breastfeeding; hence, an alternate agent may be preferred, especially while nursing a newborn or preterm infant.
