Adult Dosing

Exogenous Obesity

• Usual dose: 15-30 mg PO 1-2 hr before or after breakfast
• For tablets dose can be adjusted; 1/2 tab (18.75 mg)/day; alt: 1/2 (18.75 mg) bid
• Max: 37.5 mg/day

• Do not cut, crush or chew the capsule
• Avoid late evening medication as it may result to insomnia
• Use lowest effective dose; discontinue the drug if tolerance occurs

Pediatric Dosing

Exogenous Obesity

> 16 yrs

• Usual dose: 15-30 mg PO 1-2 hr before or after breakfast
• For tablets dose can be adjusted; 1/2 tab (18.75 mg)/day; alt: 1/2 (18.75 mg) bid
• Max: 37.5 mg/day

• Do not cut, crush or chew the capsule
• Avoid late evening medication as it may result to insomnia
• Use lowest effective dose; discontinue the drug if tolerance occurs

[Outline]

• Adult Dosing
• Pediatric Dosing

• Short-term adjunct to diet plan in a regimen of weight reduction based, behavioral modification and caloric restriction in a treatment of exogenous obesity in patients with BMI >30 kg/m² or 27 kg/m² in the presence of other risk factors

• Hypersensitivity to any of the ingredients of the product
• Advanced arteriosclerosis
• Cardiovascular disease
• Moderate to severe hypertension
• Hyperthyroidism
• Idiosyncrasy to the sympathomimetic amines
• Glaucoma
• Agitated states
• History of drug abuse
• Monoamine oxidase inhibitors
• Avoid abrupt withdrawal
• Pregnancy
• Breastfeeding

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Coadministration of other medications including SSRI's phentermine for weight loss is not recommended
• Primary pulmonary hypertension (PPH) has been reported in patients receiving a combination of phentermine with fenfluramine or dexfenfluramine; discontinue the therapy in patients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or lower extremity edema
• Serious regurgitant cardiac valvular disease has been often reported when therapy is given with other concomitant medication. Valvulopathy may occur when medication is taken as monotherapy
• If tolerance develops dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued
• Therapy may impair the ability of the patient to engage in hazardous activities such as operating machinery or driving a motor vehicle; thus patient should be cautioned accordingly
• Risk of cognitive or motor function impairment
• May cause adverse drug reaction with alcohol use
• Suprenza 15 mg and 30 mg ODT contains FD&C Yellow No. 5 (tartrazine), which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals, and commonly seen in patients who also have aspirin hypersensitivity

Caution: Use cautiously in

• Mild hypertension
• Diabetes mellitus

Adipex-P, Suprenza interacts with :

	Azilect
	Eldepryl
	Emsam
	Furazolidone
	Furoxone
	Isocarboxazid
	Linezolid
	Marplan
	Methblue
	Methylene Blue
	Nardil
	Parnate
	Phenelzine
	Rasagiline
	Safinamide
	Selegiline
	Tranylcypromine
	Urolene Blue
	Xadago
	Zelapar
	Zyvox

Pregnancy Category:C

Breastfeeding: Due to the potential for serious adverse reactions in nursing infants, manufacturer recommends discontinuation of nursing or discontinuation of drug, taking into account the importance of the drug to the mother

• CV: Primary pulmonary hypertension, regurgitant cardiac valvular disease, palpitation, tachycardia, elevation of blood pressure
• PSYCHITRIC: Abuse dependency
• CNS: Overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache, psychotic episodes
• GI: Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances
• DERM: Urticaria
• ENDO: Impotence, changes in libido

• Anorexiant; raises levels of leptin which signal satiety center in brain, causing appetite suppression
• Metabolized by liver
• Excretion: Unknown
• Half-life: 16-31 hrs

US Trade Name(s)

• Adipex-P
• Suprenza

US Availability

phentermine (generic)

• TABS: 37.5 mg
• CAPS: 15, 30, 37.5 mg

Adipex-P

• TABS: 37.5 mg
• CAPS: 37.5 mg

Suprenza

• ODT TABS: 15, 30, 37.5 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Endocrine/Metabolic

Anorexiants

Pricing data from www.DrugStore.com in U.S.A.

• Adipex-P 37.5 MG TABS [Bottle] (GATE)
  10 mg = $32.99
  20 mg = $54.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

• Adipex-P 37.5 MG Oral Capsule (TEVA PHARMACEUTICALS USA)
• Adipex-P 37.5 MG Oral Tablet (Physicians Total Care, Inc.)
• Adipex-P 37.5 MG Oral Tablet (TEVA PHARMACEUTICALS USA)
• Ionamin 15 MG Extended Release Capsule (Celltech Pharmaceuticals, Inc. )
• Ionamin 30 MG Extended Release Capsule (Celltech Pharmaceuticals, Inc. )
• Phentermine Hydrochloride 18.8 MG (Phentermine 15 MG) Oral Capsule (Actavis Totowa LLC)
• Phentermine Hydrochloride 18.8 MG (Phentermine 15 MG) Oral Capsule (Sandoz Inc.)
• Phentermine hydrochloride 15 MG (phentermine 12 MG) Oral Capsule (Apotheca, Inc.)
• Phentermine hydrochloride 30 MG (phentermine 24 MG) Oral Capsule (Actavis Totowa LLC)
• Phentermine hydrochloride 30 MG (phentermine 24 MG) Oral Capsule (Apotheca, Inc.)
• Phentermine hydrochloride 30 MG (phentermine 24 MG) Oral Capsule (Lannett Company, Inc.)
• Phentermine hydrochloride 30 MG (phentermine 24 MG) Oral Capsule (Mutual Pharmaceutical)
• Phentermine hydrochloride 30 MG (phentermine 24 MG) Oral Capsule (Sandoz Inc.)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Capsule (Actavis Totowa LLC)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Capsule (Apotheca, Inc.)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Actavis Elizabeth LLC)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Actavis Totowa LLC)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Apotheca, Inc.)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Blenheim Pharmacal, Inc.)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Keltman Pharmaceuticals Inc.)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Lannett Company, Inc.)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Mutual Pharmaceutical)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Qualitest Pharmaceuticals)
• Phentermine hydrochloride 37.5 MG (phentermine 30 MG) Oral Tablet (Rebel Distributors Corp.)