Adult Dosing
Analgesic, Antipyretic, Promoting sleep
Excedrin PM, Midol PM
- 2 tabs [1000 mg/76 mg] PO qhs PRN
- Max: 2 tabs [1000 mg/76 mg]/day
Goody's PM
- 2 packets [1000 mg/76 mg] PO qhs PRN
- Max: 2 packets [1000 mg/76 mg]/day
Unisom PM Pain SleepCaps
- 1 tab [325 mg/50 mg] PO qhs PRN
- Max: 1 tab [325 mg/50 mg]/day
Tylenol PM
- 2 tabs/caps or 30 mL soln [1000 mg/50 mg] PO qhs PRN
- Max: 2 tabs/caps or 30 mL soln [1000 mg/50 mg]/day
Analgesic, Antipyretic, Antihistaminic
Percogesic
- 1-2 tabs [325 mg/12.5 mg-650 mg/25 mg] PO q4 hrs PRN
- Max: 8 tabs [2600 mg/100 mg]/day
Percogesic Extra Strength
- 2 tabs [1000 mg/25 mg] PO q6 hrs PRN
- Max: 8 tabs [4000 mg/100 mg]/day
Tylenol Severe Allergy
- 2 tabs [1000 mg/25 mg] PO q4-6 hrs PRN
- Max: 8 tabs [4000 mg/100 mg]/day
Pediatric Dosing
Analgesic, Antipyretic, Promoting sleep
Excedrin PM, Midol PM
- >12 yrs
- 2 tabs [1000 mg/76 mg] PO qhs PRN
- Max: 2 tabs [1000 mg/76 mg]/day
Goody's PM
- >12 yrs
- 2 packets [1000 mg/76 mg] PO qhs PRN
- Max: 2 packets [1000 mg/76 mg]/day
Unisom PM Pain SleepCaps
- >12 yrs
- 1 tab [325 mg/50 mg] PO qhs PRN
- Max: 1 tab [325 mg/50 mg]/day
Tylenol PM
- >12 yrs
- 2 tabs/caps or 30 mL soln [1000 mg/50 mg] PO qhs PRN
- Max: 2 tabs/caps or 30 mL soln [1000 mg/50 mg]/day
Analgesic, Antipyretic, Antihistaminic
Percogesic
- >12 yrs
- 1-2 tabs [325 mg/12.5 mg-650 mg/25 mg] PO q4 hrs PRN
- Max: 8 tabs [2600 mg/100 mg]/day
Percogesic Extra Strength
- >12 yrs
- 2 tabs [1000 mg/25 mg] PO q6 hrs PRN
- Max: 8 tabs [4000 mg/100 mg]/day
Tylenol Severe Allergy
- >12 yrs
- 2 tabs [1000 mg/25 mg] PO q4-6 hrs PRN
- Max: 8 tabs [4000 mg/100 mg]/day
[Outline]
See Supplemental Patient Information
- Severe liver damage may occur on exceeding recommended dosages or concurrent use with other drugs containing acetaminophen. Adults having
3 alcoholic drinks every day during therapy are more susceptible for this risk. Avoid using acetaminophen/diphenhydramine combination drug with any other drug containing acetaminophen - Undertake detailed medical history of patients for presence of any liver disease, breathing problems such as emphysema or chronic bronchitis, glaucoma, urinary obstruction, or prostatic hypertrophy; before initiating therapy, ask patients if they are having treatment with any blood thinning agents such as warfarin, sedatives or tranquilizers
- All patients undergoing treatment especially children are prone to excitability
- Significant drowsiness may occur during therapy; avoid concomitant use of alcoholic beverages, alcohol, sedatives and tranquilizers as they may worsen drowsiness
- Discontinue therapy and consult a clinician if sleeplessness persists continuously for more than 2 wks, new symptoms occur, redness or swelling is noted, pain gets worse or lasts more than 10 days, or if fever gets worse or lasts for more than 3 days; further evaluate the patients as these could be signs of a serious underlying medical condition
Cautions: Use cautiously in
- Renal impairment (long-term use)
- Hepatic impairment
- Asthma
- Bladder neck obstruction
- Chronic alcoholism
- Cardiovascular disease
- Hypertension
- Hyperthyroidism
- Severe hypovolemia
- Chronic malnutrition
- PKU (phenylalanine-containing forms)
- Poor CYP2D6 metabolizer
- Concomitant use with CNS depressants
- COPD
- GI obstruction
- Angle-closure glaucoma
- Increased intraocular pressure
- Symptoms of lower respiratory tract
- Prostatic hypertrophy
- Peptic ulcer disease
- High environmental temperature
- Elderly patients
Supplemental Patient Information
- Advise patients to consult their clinician/pharmacist if they are unsure whether a drug contains acetaminophen
- Instruct patients undergoing treatment to exercise caution while driving a motor vehicle or operating machinery
- Advise women of childbearing potential to stop use of this combination drug if they are pregnant, breastfeeding, or having intention of becoming pregnant
- Inform patients to keep this drug out of reach of children
Pregnancy Category:NR
Breastfeeding: Acetaminophen component of this combination drug is a good choice for analgesia and for fever reduction in nursing mothers. Amounts excreted in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare. Small, occasional doses of diphenhydramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly when used in combination with a sympathomimetic agent or when lactation is not well established. The nonsedating antihistamines are preferred alternatives. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT). Maternal medication of acetaminophen is usually compatible with breastfeeding; no observable change was seen in the nursing infant while the mother was ingesting the compound. This information is based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776/T6 last accessed 23 June, 2011). Manufacturer advises to consult a health professional.
US Trade Name(s)
- Excedrin PM
- Midol PM
- Percogesic
- Percogesic Extra Strength
- Tylenol Severe Allergy
- Tylenol PM
- Unisom PM Pain SleepCaps
- Goody's PM
US Availability
Excedrin PM, Midol PM (acetaminophen/diphenhydramine)
Percogesic (acetaminophen/diphenhydramine)
Percogesic Extra Strength, Tylenol Severe Allergy (acetaminophen/diphenhydramine)
Tylenol PM (acetaminophen/diphenhydramine)
- CAPS: 500 mg/25 mg
- TABS: 500 mg/25 mg
- SOLN: [500 mg/25 mg]/15 mL
Unisom PM Pain SleepCaps (acetaminophen/diphenhydramine)
Goody's PM (acetaminophen/diphenhydramine)
Canadian Trade Name(s)
Canadian Availability
UK Trade Name(s)
UK Availability
CalCold Six Plus (paracetamol/diphenhydramine)
- SOLN: [120 mg/12.5 mg]/5 mL
Australian Trade Name(s)
Australian Availability
[Outline]