- Initial dose = body weight (kg) x desired factor IX increase (% or IU/dL) x reciprocal of observed recovery (IU/dL per IU/kg)
- Minor bleeding/perioperative management
- Individualize dose IV q12-24 hrs x 1-2 days
- Desired factor IX level = 20-30%
- Moderate bleeding/perioperative management
- Individualize dose IV q12-24 hrs; treat until bleeding stops and healing begins (2-7 days)
- Desired factor IX level = 25-50%
- Major bleeding/perioperative management
- Individualize dose IV q12-24 hrs x 7-10 days
- Desired factor IX level = 50-100%
- For incremental recovery of 0.8 IU/dL, calculate the dose as (IU) = [wt (kg) x desired factor IX increase (% or IU/dL) x 1.3 dL/kg]
- Minor bleeding
- Individualize dose IV q12-24 hrs atleast 1 day, until healing is achieved
- Desired factor IX level .= 20-30%
- Moderate bleeding
- Individualize dose IV q12-24 hrs; treat until bleeding stops and healing begins (2-7 days)
- Desired factor IX level = 25-50%
- Major bleeding
- Individualize dose IV q12-24 hrs x 7-10 days
- Desired factor IX level = 50-100%
- For incremental recovery of 0.9 IU/dL, calculate the dose as (IU) = [wt (kg) x desired factor IX increase (% or IU/dL) x 1.1 dL/kg]
- Minor and Moderate bleeding
- Circulating Factor IX level required 30-60 IU/dL. Repeat every 48 hours if there is further evidence of bleeding
- Major bleeding
- Circulating Factor IX level required 80-100 IU/dL. Consider a repeat dose after 6-10 hours and then every 24 hours for the first 3 days
- Due to the long half-life of therapy, the dose may be reduced and frequency of dosing may be extended after day 3 to every 48 hours or longer until bleeding stops and healing is achieved
- Dosage and duration of treatment for all factor IX products depend on the severity of factor IX deficiency, the location and extent of bleeding, and the patient’s clinical condition, age and recovery of factor IX
- Refer packahe insert for preparation and reconstitution procedure
- Minor surgery
- Individualize dose IV q12-24 hrs atleast 1 day, until healing is achieved
- Desired factor IX level = 30-60%
- Major surgery
- Individualize dose IV q8-24 hrs x 7-10 days
- Desired factor IX level = 80-100%
Hemophilia B, Routine Prophylaxis
- 40-60 IU/kg IV bolus; not to exceed infusion rate of 10 mL/min
- Minor surgery
- Circulating Factor IX level required 50-80 IU/dL. Repeat as needed after 24-48 hours until bleeding stops and healing is achieved
- Major surgery
- Circulating Factor IX level required 60-100 IU/dL. Consider a repeat dose after 6-10 hours and then every 24 hours for the first 3 days
- Initial dose = body weight (kg) x desired factor IX increase (% or IU/dL) x reciprocal of observed recovery (IU/dL per IU/kg)
- Children <15 yrs: Estimated dose (units) = [wt (kg) x desired factor IX level (% or IU/dL) x 1.4 (IU/kg per IU/dL)]
- Children >15 yrs: Estimated dose (units) = [wt (kg) x desired factor IX level (% or IU/dL) x 1.3 (IU/kg per IU/dL)]
- Minor bleeding/perioperative management
- Individualize dose IV q12-24 hrs x 1-2 days
- Desired factor IX level = 20-30%
- Moderate bleeding/perioperative management
- Individualize dose IV q12-24 hrs; treat until bleeding stops and healing begins (2-7 days)
- Desired factor IX level = 25-50%
- Major bleeding/perioperative management
- Individualize dose IV q12-24 hrs x 7-10 days
- Desired factor IX level = 50-100%
- For incremental recovery of 0.7 IU/dL, the dose is calculated as: Dose (IU) = body weight (kg) x desired factor IX increase (% or IU/dL) x 1.4 dL/kg
- In pediatric patients <15 yrs of age, 1 IU/kg will increase the circulating level of factor IX by approx 0.7% [IU/dL] of normal
- In pediatric patients >15 yrs of age, 1 IU/kg will increase the circulating level of factor IX by approx 0.8% [IU/dL] of normal
- Dosage and duration of treatment for all factor IX products depend on the severity of factor IX deficiency, the location and extent of bleeding, and the patient’s clinical condition, age and recovery of factor IX
- Minor and Moderate bleeding for > 12 yrs
- Circulating Factor IX level required 30-60 IU/dL. Repeat every 48 hours if there is further evidence of bleeding
- Major bleeding for > 12 yrs
- Circulating Factor IX level required 80-100 IU/dL. Consider a repeat dose after 6-10 hours and then every 24 hours for the first 3 days
- Due to the long half-life of therapy, the dose may be reduced and frequency of dosing may be extended after day 3 to every 48 hours or longer until bleeding stops and healing is achieved
- Minor surgery for > 12 yrs
- Circulating Factor IX level required 50-80 IU/dL. Repeat as needed after 24-48 hours until bleeding stops and healing is achieved
- Major surgery for > 12 yrs
- Circulating Factor IX level required 60-100 IU/dL. Consider a repeat dose after 6-10 hours and then every 24 hours for the first 3 days
