naphazoline/zinc [Ophthalmic]

Adult Dosing

Ocular decongestant, astringent

Instill 1-2 gtt in the affected eye(s) qid

Pediatric Dosing

Ocular decongestant, astringent

Instill 1-2 gtt in the affected eye(s) qid

[Outline]

Adult Dosing
Pediatric Dosing

Indications ⬆ ⬇

Temporarily relieves ocular redness, burning, or dryness due to minor eye irritations
To clear mucus build-up from the outer surface of the eye caused by dust, pollen, or smoke
For use as a protectant against further ocular irritation or for relieving ocular dryness

Contraindications ⬆ ⬇

Hypersensitivity to any of the ingredients of the product
Angle-closure glaucoma
Concomitant use or use within 14 days of discontinuing MAO inhibitors

Black Box Warnings ⬆ ⬇

Dosing Adjustment ⬆ ⬇

Renal Dose Adjustment

Renal impairment: No dose adjustments

Hepatic Dose Adjustment

Hepatic impairment: No dose adjustments

Warnings/Precautions ⬆ ⬇

See Supplemental Patient Information

Naphazoline component of this combination drug may occasionally cause systemic sympathomimetic effects such as headache, hypertension, cardiac irregularities, nervousness, nausea, dizziness, weakness, and sweating. Drowsiness, decreased body temperature, bradycardia, shock-like hypotension, and coma may occur on overdosage
Rebound congestion, characterized by reactive hyperemia may occur with prolonged use and may result in overuse of the drug
Naphazoline component may liberate pigment granules presumably from the iris when used in high doses in elderly patients
Do not use this combination drug continuously for longer than 2-3 days without consulting a physician as chronic use may damage the blood vessels in the eyes
Advise patients to discontinue therapy if they experience ocular pain, vision changes, continued ocular redness/irritation, worsening of condition or if their symptoms last >72 hrs
Advise patients to avoid using contact lenses during treatment period
Use caution when driving, operating machinery, or performing other hazardous activities as the product may cause temporary vision changes
Before prescribing this drug, undertake medical history of patients for presence of narrow angle glaucoma
Do not touch the eyelids or surrounding areas with the dropper tip as this could contaminate the medication and result in serious ocular infections. Replace cap after using
Overdosage may produce increased ocular redness; pupils may get enlarged temporarily
On accidental swallowing of this drug, advise patients to seek medical help or immediately contact a Poison Control Center

Cautions: Use cautiously in

Hypertension
Cardiovascular disease
Diabetes mellitus
Hyperthyroidism
Infections or injury
Geriatric patients

Supplemental Patient Information

Instruct patients wearing soft contact lenses to remove them prior to administration of the drug and to wait at least 15 minutes after instillation
Instruct patients to avoid use if the drug solution changes color or becomes cloudy
Instruct patients to store this drug out of reach of children

Pregnancy/Breast Feeding ⬆ ⬇

Pregnancy Category:C

Breastfeeding: Safety unknown. Manufacturer advises nursing mothers to avoid using this combination drug without consulting their clinician.

Adverse Reactions ⬆ ⬇

EENT: Ongoing or worsening eye redness, eye pain, vision changes, mydriasis, buzzing in ears, burning, transient ocular stinging, blurred vision, ocular irritation, watery eyes, increased lacrimation, elevated IOP, punctate keratitis
HYPERSENSITIVITY: Allergic reactions including hives, difficulty breathing; swelling of the face, lips, tongue, or throat
CNS: Dizziness, headache, confusion, anxiety, nervousness, drowsiness, weakness, CNS depression (patients <6 yrs)
CV: Chest pain, cardiac irregularities, hypertension
GI: Nausea
ENDO: Hyperglycemia
DERM: Sweating

Clinical Pharmacology ⬆ ⬇

Naphazoline

Ophthalmic decongestant (sympathomimetic); reduces ocular congestion and redness by stimulating alpha adrenergic receptors
Metabolism: Unknown
Excretion: Unknown
Half-life: Unknown

Zinc sulfate