Adult Dosing

Asthma maintenance

• Immediate release
• 600 mg PO qid
• Max: 2400 mg/day

• Extended release
• 1200 mg PO bid
• Max: 2400 mg/day
• Give within one hour after morning and evening meals
• Do not cut/crush/chew extended release tabs

Pediatric Dosing

Asthma maintenance

Child 12 yrs

• Immediate release
• 600 mg PO qid
• Max: 2400 mg/day

• Extended release
• 1200 mg PO bid
• Max: 2400 mg/day
• Give within one hour after morning and evening meals
• Do not cut/crush/chew extended release tabs

[Outline]

• Adult Dosing
• Pediatric Dosing

• Zileuton is indicated for the prophylaxis and chronic treatment of asthma in adults and children > 12 years

• Hypersensitivity to any of the ingredients of the product
• Active liver disease
• LFTs 3 x ULN

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Active hepatic disease: Contraindicated
• Baseline LFTs 3 x ULN: Contraindicated

• Zileuton is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Therapy may be continued during acute exacerbations of asthma
• Elevations of hepatic function enzymes and bilirubin may occur. Assess ALT/ prior to starting therapy, qmo x 3 mo, q2-3 mo x 9, and periodically thereafter
• Use cautiosly in patients who consume substantial quantities of alcohol and/or have a history of liver disease
• Neuropsychiatric events, including sleep disorders and behavior changes, may occur with therapy. Instruct patients to be alert for neuropsychiatric events and to notify healthcare professional should these events occur Evaluate the risks and benefits of continuing treatment
• Concurrent theophylline results doubling of serum theophylline concentrations. Decrease theophylline dose

Zyflo, Zyflo CR interacts with :

	Asenapine
	Clozapine
	Clozaril
	Elixophyllin
	Fazaclo ODT
	Hetlioz
	Juxtapid
	Lomitapide
	Olanzapine
	Ramelteon
	Rozerem
	Saphris
	Tasimelteon
	Theo-24
	Theochron
	Theolair
	Theophylline
	Tizanidine
	Versacloz
	Zanaflex
	Zyprexa
	Zyprexa Relprevv
	Zyprexa Zydis

Pregnancy Category:C

Breastfeeding: Safety unknown. An alternate drug may be preferred, especially while nursing a newborn or preterm infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 23 April 2010).

• EENT: Pharyngolaryngeal pain, sinusitis, conjunctivitis
• CNS: Headache, sleep disorders, behavior changes, hypertonia
• CV: Chest pain
• GI: Nausea, abdominal pain, diarrhea, constipation, dyspepsia, flatulence, vomiting
• GU: Urinary tract infection, vaginitis
• HEMA: Leukopenia, lymphadenopathy
• DERM: Pruritus
• MUSC: Arthralgia, myalgia, neck pain

• Leukotriene inhibitor; inhibits the enzyme 5-lipoxygenase that catalyzes the formation of leukotrienes. Interferes with leukotriene formation
• Metabolized by liver; CYP450: 1A2, 2C9, 3A4 substrate
• Excreted in urine (94.5%) and feces (2.2%)
• Half-life (Immediate release): 2.5 hrs
• Half-life (Extended release): 3.2 hrs

US Trade Name(s)

• Zyflo
• Zyflo CR

US Availability

Zyflo

• TABS: 600 mg

Zyflo CR

• ETABS: 600 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

ENT

Leukotriene Modifiers

Pulmonary

Leukotriene Modifiers

Pricing data from www.DrugStore.com in U.S.A.

• Zyflo CR 600 MG TB12 [Bottle] (CORNERSTONE BIOPHARMA)
  60 mg = $493.99
  120 mg = $977.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

• Zyflo 600 MG 12 HR Extended Release Tablet (Cornerstone Therapeutics Inc.)
• Zyflo 600 MG 12 HR Extended Release Tablet (Critical Therapeutics, Inc.)
• Zyflo 600 MG Oral Tablet (Cornerstone Therapeutics Inc.)
• Zyflo 600 MG Oral Tablet (Critical Therapeutics Inc.)