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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Antimicrobials:


Comment:

Bedaquiline is metabolized by CYP3A4 and concurrent administration of CYP3A4 inhibiting antimicrobials may increase the risk of bedaquiline toxicity. Bedaquiline can produce hepatotoxicity and can prolong the QTc interval, thus increasing the risk of ventricular arrhythmias.


Class 3: Assess Risk & Take Action if Necessary