Adult Dosing
Chronic urea-splitting urinary infections
- Start with 250 mg PO tid-qid; Alt: 12 mg/kg/day PO tid-qid. A total dose of 10-15 mg/kg/day PO in divided doses is recommended
- Max: 1.5 g/day
Pediatric Dosing
Chronic urea-splitting urinary infections [Not FDA approved]
- Start with 10 mg/kg/day PO given in 2-3 divided doses; adjust the dose according to individual tolerance and response, using the lowest possible effective dose
Notes:- This dose has been tolerated satisfactorily in children 8-10 yrs of age for periods up to 1 yr
- Carefully monitor patient's clinical condition and hematologic status during treatment
- Detailed studies involving dosage have not been performed in children; above mentioned dosage is an approximate dosage at which children may benefit
[Outline]
- Coombs negative hemolytic anemia may occur during acetohydroxamic acid therapy; a mild reticulocytosis without anemia is even more prevalent. Cases of severe hemolytic anemia are usually associated with gastrointestinal upset evidenced by anorexia, nausea, vomiting, and generalized malaise
- Bone marrow suppressant effect of the drug has occurred in experimental animals receiving high doses of acetohydroxamic acid; however, this effect is not seen in humans
- Monitor CBC and reticulocyte count at 3-month intervals for the duration of treatment and LFTs periodically
- Adverse GI effects including nausea, vomiting, anorexia, diarrhea, and constipation have been evidenced in certain patients. Many of these symptoms were mild, transitory, and did not result in treatment interruption
- Depression, anxiety, nervousness, and tremulousness have been reported in certain patients receiving therapy
- Alopecia and scalp tenderness have been reported in some patients
- Mild headaches have been reported during the first 48 hrs of treatment
- A non-pruritic macular skin rash has been reported in the upper extremities and on the face of several patients receiving this drug on a long-term basis, especially when taken concomitantly with alcoholic beverages
- Superficial phlebitis involving the lower extremities has occurred in several patients undergoing therapy; these vascular abnormalities have returned to normal following appropriate medical therapy
- Acetohydroxamic acid should not be used as a substitute for appropriate anti-infective and/or surgical removal of a urinary calculus when indicated
Cautions: Use cautiously in
- Preexisting thrombophlebitis or phlebothrombosis
- Advanced renal disease
Pregnancy Category:X
Breastfeeding: Safety unknown. It is not known if acetohydroxamic acid is excreted in breast milk. However, due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or to discontinue the drug, analyzing the importance of the drug to the mother.
Pricing data from www.DrugStore.com in U.S.A.
- Lithostat 250 MG TABS [Bottle] (MISSION)
100 mg = $169.98
300 mg = $499.96
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
